Mechanism of eosinophil infiltration in the patient with subcutaneous angioblastic lymphoid hyperplasia with eosinophilia (Kimura's disease). Mechanism of eosinophil chemotaxis mediated by candida antigen and IL-5.
Mechanism of eosinophil infiltration in the patient with subcutaneous angioblastic lymphoid hyperplasia with eosinophilia (Kimura's disease). Mechanism of eosinophil chemotaxis mediated by candida antigen and IL-5.
复制标题
皮下血管母细胞淋巴样增生伴嗜酸性粒细胞增多（木村氏病）患者嗜酸性粒细胞浸润的机制。
DOI：
10.1159/000236740
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发表时间：
1994
影响因子：
2.8
通讯作者：
K. Togawa
中科院分区：
文献类型：
--
作者：
N. Terada;A. Konno;K. Shirotori;T. Fujisawa;J. Atsuta;R. Ichimi;Y. Kikuchi;S. Takaki;K. Takatsu;K. Togawa
木村氏病是一种病因不明的慢性肉芽肿性疾病。虽然嗜酸性粒细胞增多是本病的特征性表现之一，但其发病机制尚不清楚。在本研究中，它被证明，白细胞介素-5（IL-5）的产生和释放的肉芽肿和淋巴结的网站后，刺激念珠菌抗原。还表明，木村病患者的外周血嗜酸性粒细胞中含有大比例的低密度嗜酸性粒细胞，并且其活力延长。这些结果有力地表明，局部产生的白细胞介素-5诱导的念珠菌抗原有助于在这种疾病的嗜酸性粒细胞增多症。
Kimura's disease is a chronic granulomatous disease of unknown etiology. Although eosinophilia is one of the characteristic features in this disease, little is known about the mechanism of eosinophilia. In the present study it was demonstrated that interleukin-5 (IL-5) was produced and released from the site of a granuloma and lymph nodes after stimulation with candida antigen. It was also shown that peripheral blood eosinophils from patients with Kimura's disease contained a large proportion of hypodense eosinophils and that their viability was prolonged. These results strongly suggest that locally produced IL-5 induced by candida antigen contributes to the eosinophilia in this disease.