Impact of obesity on diagnosis and treatment of breast cancer
Impact of obesity on diagnosis and treatment of breast cancer
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DOI：
10.1007/s10549-009-0459-1
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发表时间：
2010-02-01
影响因子：
3.8
通讯作者：
Verkooijen, Helena Marieke
中科院分区：
文献类型：
--
作者：
Deglise, Carole;Bouchardy, Christine;Verkooijen, Helena Marieke
在这项以人群为基础的研究中，我们评估了肥胖对乳腺癌的表现、诊断和治疗的影响。在2003年至2005年期间在瑞士日内瓦被诊断为浸润性乳腺癌的所有女性中，我们确定了那些拥有身体质量指数(BMI)信息的女性，并将她们归类为正常/体重不足(BMI<；25 kg/m(2))、超重(BMI a Parts/1000yena Euro“<；30 kg/m(2))和肥胖(BMI a Parts/1000 Yena30 kg/m(2))。采用多因素Logistic回归分析，比较不同组间肿瘤、诊断和治疗特点。肥胖女性出现III-IV期疾病的频率明显更高(调整后的优势比[ORADJ]：1.8，95%CI：1.0-3.3)。肥胖患者与正常/体重不足患者相比，肿瘤千分之1厘米和pn2-N3淋巴结明显更难触及(ORADJ 2.4，[1.1-5.3]和ORADJ 5.1，[1.0-25.4])。肥胖女性接受超声(ORADJ 0.5，[0.3-0.9])和核磁共振(ORADJ 0.3，[0.1-0.6])的可能性较小，延长住院时间的风险较高(ORADJ 4.7，[2.0-10.9])。这项研究发现了肥胖和瘦女性之间重要的诊断和治疗差异，这可能会影响患有乳腺癌的肥胖女性的存活率。需要采取具体的战略来优化对患有乳腺癌或有患乳腺癌风险的肥胖妇女的护理。
In this population-based study, we evaluated the impact of obesity on presentation, diagnosis and treatment of breast cancer. Among all women diagnosed with invasive breast cancer in the canton Geneva (Switzerland) between 2003 and 2005, we identified those with information on body mass index (BMI) and categorized them into normal/underweight (BMI < 25 kg/m(2)), overweight (BMI a parts per thousand yenaEuro"< 30 kg/m(2)) and obese (BMI a parts per thousand yen30 kg/m(2)) women. Using multivariate logistic regression, we compared tumour, diagnosis and treatment characteristics between groups. Obese women presented significantly more often with stage III-IV disease (adjusted odds ratio [ORadj]: 1.8, 95% CI: 1.0-3.3). Tumours a parts per thousand yen1 cm and pN2-N3 lymph nodes were significantly more often impalpable in obese than in normal/underweight patients (ORadj 2.4, [1.1-5.3] and ORadj 5.1, [1.0-25.4], respectively). Obese women were less likely to have undergone ultrasound (ORadj 0.5, [0.3-0.9]) and MRI (ORadj 0.3, [0.1-0.6]) and were at increased risk of prolonged hospital stay (ORadj 4.7, [2.0-10.9]). This study finds important diagnostic and therapeutic differences between obese and lean women, which may impair survival of obese women with breast cancer. Specific strategies are needed to optimize the care of obese women with or at risk of breast cancer.