A Practical Testing Battery to Measure Neurobehavioral Ability among Children with FASD.
A Practical Testing Battery to Measure Neurobehavioral Ability among Children with FASD.
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DOI：
10.7895/ijadr.v2i3.83
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发表时间：
2013-11-26
影响因子：
0.7
通讯作者：
Adnams CM
中科院分区：
文献类型：
--
作者：
Kalberg WO;May PA;Blankenship J;Buckley D;Gossage JP;Adnams CM
确定一个简短，实用的测试电池，区分胎儿酒精谱系障碍（FASD）和未暴露的控制儿童。孩子们接受了畸形学检查，一组有针对性的认知和行为测试，他们的母亲接受了关于母亲风险因素的采访。诊断为FASD的儿童和产前未接触酒精的儿童在认知/行为测试结果上进行了比较。南非西开普省的一个社区。61名一年级FASD儿童和52名匹配的正常对照儿童。母亲饮酒行为与其子女考试成绩之统计分析。自我报告的母亲饮酒模式之前，期间和怀孕后，被用来确认产前暴露于酒精在一组儿童诊断为FASD。与此样本的儿童诊断为FASD和完全未暴露的控制，母亲饮酒对儿童的表现的不利影响的报告。标准化认知和行为测试的结果表明，两组在以下方面存在高度显著性差异（p ≤ 0.001）：智力、知觉运动、规划以及逻辑、空间、短期、长期和工作记忆能力。此外，只有3个特定的认知和行为测试，包括数字跨度A+B（Wald = 4.10），荒谬的情况（Wald = 3.57），和单词联想（Wald = 4.30）的二元逻辑回归模型正确分类79.1%的儿童参与者为FASD或控制。一套简单实用的测试可以区分患有和没有FASD的儿童，并为受影响儿童的干预措施提供有用的信息。
To determine a brief, practical battery of tests that discriminate between children with a fetal alcohol spectrum disorder (FASD) and unexposed controls. Children received dysmorphology exams, a targeted battery of cognitive and behavioral tests, and their mothers were interviewed about maternal risk factors. Children diagnosed with an FASD and children unexposed to alcohol prenatally were compared on cognitive/behavioral test results. A community in The Western Cape Province of South Africa. Sixty-one, first grade children with FASD and 52 matched normal controls. Statistical analyses of maternal drinking behavior and their child's test performance. Self-reported maternal drinking patterns before during and after pregnancy were used to confirm prenatal exposures to alcohol in the group of children diagnosed with FASD. With this sample of children diagnosed with FASD and completely unexposed controls, the adverse effects of maternal drinking on children's performance are reported. Results of the battery of standardized cognitive and behavioral tests indicate highly significant differences (p ≤ .001) between groups on: intelligence, perceptual motor, planning, and logical, spatial, short term, long term, and working memory abilities. Furthermore, a binary logistical regression model of only 3 specific cognitive and behavioral tests, including Digit Span A+B (Wald = 4.10), Absurd Situation (Wald = 3.57), and Word Association (Wald = 4.30) correctly classified 79.1% of the child participants as FASD or controls. A brief, practical set of tests can discriminate children with and without FASD and provide useful information for interventions for affected children.