Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve
Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve
复制标题
DOI：
10.3390/chemengineering4030048
复制
发表时间：
2020-09-01
期刊：
影响因子：
2.5
通讯作者：
Alexiadis, Alessio
中科院分区：
文献类型：
--
作者：
Mohammed, Adamu Musa;Ariane, Mostapha;Alexiadis, Alessio
本研究提出了一种基于 3D 粒子（离散）的多物理场方法来模拟主动脉瓣钙化。模拟不同阶段的钙化（从轻度到重度），并评估它们对心输出量的影响。心脏流速随着钙化程度的增加而降低。特别是，存在一个临界钙化水平，低于该水平时流速急剧下降。还计算了膜上的机械应力。结果表明，随着钙化的进展，会出现高机械应力的斑点。首先，它们集中在连接两个传单的区域；当达到严重钙化时，它们会延伸到瓣膜底部的区域。
This study proposes a 3D particle-based (discrete) multiphysics approach for modelling calcification in the aortic valve. Different stages of calcification (from mild to severe) were simulated, and their effects on the cardiac output were assessed. The cardiac flow rate decreases with the level of calcification. In particular, there is a critical level of calcification below which the flow rate decreases dramatically. Mechanical stress on the membrane is also calculated. The results show that, as calcification progresses, spots of high mechanical stress appear. Firstly, they concentrate in the regions connecting two leaflets; when severe calcification is reached, then they extend to the area at the basis of the valve.