Bisphosphonates-related osteonecrosis of the jaws: a concise review of the literature and a report of a single-centre experience with 151 patients
Bisphosphonates-related osteonecrosis of the jaws: a concise review of the literature and a report of a single-centre experience with 151 patients
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DOI：
10.1111/j.1600-0714.2011.01091.x
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发表时间：
2012-03-01
影响因子：
3.3
通讯作者：
Nammour, Samir
中科院分区：
文献类型：
--
作者：
Vescovi, Paolo;Merigo, Elisabetta;Nammour, Samir
颌骨骨坏死（ONJ）是2003年首次描述的长期双磷酸盐治疗（BPT）的不良副作用。BRONJ的病因仍不清楚，发病机制似乎是多因素的，与几个局部或全身因素有关。许多专家小组制定了预防方案，以促进专家参与BRONJ患者的多学科管理。在本文中，我们提出了一个简明的文献综述，我们报告了帕尔马大学的经验与151例患者，假设BPT的肿瘤（121例）和非肿瘤（30例）疾病。采用不同方法（手术和非手术、激光辅助和非激光辅助）治疗了139个BRONJ部位：在临床改善方面，发现仅采用药物治疗的组之间存在统计学显著差异;在完全愈合方面，在治疗方案中引入激光辅助方法和手术方法改善了治疗结果。口腔病理医学杂志（2012）41：214-221
The osteonecrosis of the jaws (ONJ) is an adverse side effect of long-term bisphosphonate therapy (BPT) firstly described in 2003. The aetiology of BRONJ remains unknown, and the pathogenesis seems multifactorial and related to several local or general factors. Many expert panel developed preventive protocols to facilitate specialists involved in the multidisciplinary management of BRONJ patients. In this paper, we present a concise review of the literature, and we report the experience of the University of Parma with 151 patients that assumed BPT for both oncological (121 patients) and non-oncological (30 patients) diseases. One hundred and thirtynine BRONJ sites were treated with different approaches (surgical and non-surgical, laser-assisted and non-laserassisted): in terms of clinical improvement, a statistically significant difference was found between the group treated with the only medical therapy; in terms of complete healing, the introduction in the treatment protocols of both laser-assisted approach and surgical approach improves the therapeutical results. J Oral Pathol Med (2012) 41: 214-221