Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study
Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study
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DOI：
10.1007/s00213-003-1640-6
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发表时间：
2004-03-01
影响因子：
3.4
通讯作者：
Vollenweider, FX
中科院分区：
文献类型：
--
作者：
Hasler, F;Grimberg, U;Vollenweider, FX
基本原理。5-羟色胺（5-羟色胺，5-HT）受体在感知、影响调节和注意等方面发挥重要作用。5-HT2A激动剂裸盖菇素（psilocybin， PY）的药理作用有助于研究认知和意识的神经生物学基础。PY对心理（病理）逻辑和生理参数的剂量依赖性研究。方法。8名受试者接受安慰剂（PL）， 45（“极低剂量，VLD”），115（“低剂量，LD”），215（“中剂量，MD”）和315（“高剂量，HD”）杯/公斤体重PY。采用“意识改变状态评定量表”（5D-ASC）、“法兰克福注意量表”（FAIR）和“形容词情绪评定量表”（AMRS）评估PY对心理（病理）逻辑核心维度、注意力和情绪的影响。记录24小时心电图（EKG）并测量血压。测定血浆促甲状腺激素（TSH）、催乳素（PRL）、皮质醇（CORT）、促肾上腺皮质激素（ACTH）浓度及标准临床化学参数。结果。PY剂量依赖性地增加了所有5D-ASC核心维度的评分。只有一名受试者对HD PY有短暂的焦虑反应。与PL相比，MD和HD PY在FAIR测试中的表现降低了50%。“一般失活”、“情绪兴奋性”和“多梦性”是MD和HD PY后AMRS中唯一显示得分增加的领域。平均动脉血压（MAP）在给药后仅60分钟中度升高。任何剂量的PY均不影响心电图和体温。血浆TSH、ACTH和CORT水平在HD PY的峰值效应期间升高，而PRL水平在MD和HD PY后升高。结论。PY以剂量依赖的方式影响意识状态改变的核心维度和生理参数。我们的研究没有提供理由担心PY对身体健康有害。
Rationale. Serotonin (5-Hydroxytryptamine, 5-HT) receptors play an important role in perception, affect regulation and attention. Pharmacological challenge with the 5-HT2A agonist psilocybin (PY) is useful in studying the neurobiological basis of cognition and consciousness.Objective. Investigation of dose-dependent effects of PY on psycho(patho)logical and physiological parameters. Methods. Eight subjects received placebo (PL), and 45 ("very low dose, VLD"), 115 ("low dose, LD"), 215 ("medium dose, MD"), and 315 ("high dose, HD") mug/kg body weight PY. The "Altered States of Consciousness Rating Scale" (5D-ASC), the "Frankfurt Attention Inventory" (FAIR), and the "Adjective Mood Rating Scale" (AMRS) were used to assess the effects of PY on psycho(patho)logical core dimensions, attention, and mood. A 24-h electrocardiogram (EKG) was recorded and blood pressure was measured. Plasma concentrations of thyroid-stimulating hormone (TSH), prolactin (PRL), cortisol (CORT), adrenocorticotropic hormone (ACTH), and standard clinical chemical parameters were determined. Results. PY dose dependently increased scores of all 5D-ASC core dimensions. Only one subject reacted with transient anxiety to HD PY. Compared with PL, MD and HD PY led to a 50% reduction of performance in the FAIR test. "General inactivation", "emotional excitability", and "dreaminess" were the only domains of the AMRS showing increased scores following MD and HD PY. The mean arterial blood pressure (MAP) was moderately elevated only 60 min following administration of HD PY. Neither EKG nor body temperature was affected by any dose of PY. TSH, ACTH, and CORT plasma levels were elevated during peak effects of HD PY, whereas PRL plasma levels were increased following MD and HD PY. Conclusion. PY affects core dimensions of altered states of consciousness and physiological parameters in a dose-dependent manner. Our study provided no cause for concern that PY is hazardous with respect to somatic health.