Membrane Currents, Gene Expression, and Circadian Clocks
Membrane Currents, Gene Expression, and Circadian Clocks
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DOI：
10.1101/cshperspect.a027714
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发表时间：
2017-05-01
影响因子：
7.2
通讯作者：
Colwell, Christopher S.
中科院分区：
文献类型：
--
作者：
Allen, Charles N.;Nitabach, Michael N.;Colwell, Christopher S.
哺乳动物和果蝇脑中的神经元昼夜节律振荡器表达由互锁基因转录反馈环组成的昼夜节律钟。遗传时钟通过知之甚少的信号通路调节膜电活动，以产生动作电位放电的昼夜节律模式。在白天，Na+通道为生物钟神经元的自发活动提供兴奋性驱动。多种类型的K+通道调节动作电位放电模式和神经元活动的夜间减少。膜电活动可能通过细胞内Ca 2+和环磷酸腺苷（cAMP）的变化来调节基因时钟的活性。在衰老和疾病期间，连接基因时钟和神经活动的信号通路的下降可能会削弱昼夜节律输出，并对人类健康产生重大影响。
Neuronal circadian oscillators in the mammalian and Drosophila brain express a circadian clock comprised of interlocking gene transcription feedback loops. The genetic clock regulates the membrane electrical activity by poorly understood signaling pathways to generate a circadian pattern of action potential firing. During the day, Na+ channels contribute an excitatory drive for the spontaneous activity of circadian clock neurons. Multiple types of K+ channels regulate the action potential firing pattern and the nightly reduction in neuronal activity. The membrane electrical activity possibly signaling by changes in intracellular Ca2+ and cyclic adenosine monophosphate (cAMP) regulates the activity of the gene clock. A decline in the signaling pathways that link the gene clock and neural activity during aging and disease may weaken the circadian output and generate significant impacts on human health.