The effect of subclinical infantile thiamine deficiency on motor function in preschool children
The effect of subclinical infantile thiamine deficiency on motor function in preschool children
复制标题
DOI：
10.1111/mcn.12397
复制
发表时间：
2017-10-01
影响因子：
3.4
通讯作者：
Fattal-Valevski, Aviva
中科院分区：
文献类型：
--
作者：
Harel, Yael;Zuk, Luba;Fattal-Valevski, Aviva
我们调查了婴儿硫胺素（维生素B1）缺乏对学龄前儿童运动功能的长期影响，这些儿童在生命的前2年内用有缺陷的牛奶替代品喂养。在这项回顾性队列研究中，将39名5-6岁的儿童与30名年龄匹配的健康儿童进行了比较，这些儿童在婴儿期曾接触过缺乏硫胺素的配方奶粉。采用儿童运动成套测验（M-ABC）和Zuk评定量表对受试者的运动功能进行评定。两种评估工具均显示，暴露组和未暴露组之间在大体和精细运动发育（p < .001，球技能p = .01）和图形运动发育（p = .004）方面存在统计学显著差异。在平衡控制功能（p <0.001，OR 5.4; 95% CI 3.4-7.4）和精细运动技能（p <0.001，OR 3.2; 95% CI 1.8-4.6）的M-ABC测试中，差异尤其值得注意。在暴露组中，两种评估都一致认为，与未暴露组相比，儿童表现出运动功能困难的比率较高（M-ABC：56% vs. 10%，Zuk评估：59% vs. 3%，p < .001）。婴儿期的硫胺素缺乏对儿童期的粗大和精细运动功能以及平衡技能具有长期影响，硫胺素在正常的运动发育中具有至关重要的作用。该研究强调了适当的婴儿喂养和母乳替代品的监管控制的重要性。
We investigated the long-term implications of infantile thiamine (vitamin B1) deficiency on motor function in preschoolers who had been fed during the first 2 years of life with a faulty milk substitute. In this retrospective cohort study, 39 children aged 5-6 years who had been exposed to a thiamine-deficient formula during infancy were compared with 30 age-matched healthy children with unremarkable infant nutritional history. The motor function of the participants was evaluated with The Movement Assessment Battery for Children (M-ABC) and the Zuk Assessment. Both evaluation tools revealed statistically significant differences between the exposed and unexposed groups for gross and fine motor development (p < .001, ball skills p = .01) and grapho-motor development (p = .004). The differences were especially noteworthy on M-ABC testing for balance control functioning (p < .001, OR 5.4; 95% CI 3.4-7.4) and fine motor skills (p < .001, OR 3.2; 95% CI 1.8-4.6). In the exposed group, both assessments concurred on the high rate of children exhibiting motor function difficulties in comparison to unexposed group (M-ABC: 56% vs. 10%, Zuk Assessment: 59% vs. 3%, p < .001). Thiamine deficiency in infancy has long-term implications on gross and fine motor function and balance skills in childhood, thiamine having a crucial role in normal motor development. The study emphasizes the importance of proper infant feeding and regulatory control of breast milk substitutes.