TMC-2A, -2B and -2C, new dipeptidyl peptidase IV inhibitors produced by Aspergillus oryzae A374 .2. Isolation and structure determination
TMC-2A, -2B and -2C, new dipeptidyl peptidase IV inhibitors produced by Aspergillus oryzae A374 .2. Isolation and structure determination
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DOI：
10.7164/antibiotics.50.653
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发表时间：
1997-08-01
影响因子：
3.3
通讯作者：
Komatsubara, S
中科院分区：
文献类型：
--
作者：
Asai, Y;Nonaka, N;Komatsubara, S
从曲霉AspergillusA 374发酵液中分离得到新的二肽基肽酶IV抑制剂TMC-2A、TMC-2B和TMC-2C。经化学、光谱和X-射线晶体学分析，确定其结构为由L-色氨酸、单或二羟基-L-亮氨酸和高度取代的异喹啉三部分组成的类肽化合物。
New dipeptidyl peptidase IV inhibitors, TMC-2A, -2B, and -2C, were isolated from the fermentation broth of Aspergillus oryzae A374. On the basis of chemical, spectroscopic and X-ray crystallographic analyses, their structures were established to be peptide-like compounds composed of three moieties, L-tryptophan, mono-or dihydroxy-L-leucine and highly substituted isoquinoline.