The neuropharmacology of relapse to food seeking: methodology, main findings, and comparison with relapse to drug seeking.
The neuropharmacology of relapse to food seeking: methodology, main findings, and comparison with relapse to drug seeking.
复制标题
粮食寻求食物的复发的神经药理学：方法论，主要发现和与寻求药物的复发的比较。
DOI：
10.1016/j.pneurobio.2009.05.003
复制
发表时间：
2009-09
影响因子：
6.7
通讯作者：
Shaham Y
中科院分区：
文献类型：
--
作者：
Nair SG;Adams-Deutsch T;Epstein DH;Shaham Y
食物启动和线索诱导的神经恢复机制可能与药理学应激源育亨宾诱导的神经恢复机制不同。寻找食物恢复的神经元机制可能与正在进行的食物强化操作反应不同。食物寻求恢复的神经机制与药物寻求恢复的神经机制在一定程度上重叠。旧病复发，不健康的饮食习惯是人类饮食治疗的一个主要问题。这种复发的机制尚不清楚。令人惊讶的是，直到最近，这个临床问题还没有在动物模型中进行系统的研究。在这里，我们回顾了最近的研究结果，这些研究采用恢复模型（通常用于研究滥用药物的复发）来描述药物对食物启动（非偶然暴露于少量食物），先前与食物相关的线索或注射药理学应激源育亨宾引起的食物寻求复发的影响。我们还讨论了与使用恢复模型研究食物寻求复发相关的方法学问题，食物寻求与药物寻求恢复机制的异同，以及恢复过程为研究人类复发提供合适模型的程度。最后，我们讨论了药物开发和未来研究的意义。我们提出三个初步结论：
The neuronal mechanisms of food-priming- and cue-induced reinstatement are likely different from those of reinstatement induced by the pharmacological stressor yohimbine. The neuronal mechanisms of reinstatement of food seeking are possibly different from those of ongoing food-reinforced operant responding. The neuronal mechanisms underlying reinstatement of food seeking overlap to some degree with those of reinstatement of drug seeking. Relapse to old, unhealthy eating habits is a major problem in human dietary treatments. The mechanisms underlying this relapse are unknown. Surprisingly, until recently this clinical problem has not been systematically studied in animal models. Here, we review results from recent studies in which a reinstatement model (commonly used to study relapse to abused drugs) was employed to characterize the effect of pharmacological agents on relapse to food seeking induced by either food priming (non-contingent exposure to small amounts of food), cues previously associated with food, or injections of the pharmacological stressor yohimbine. We also address methodological issues related to the use of the reinstatement model to study relapse to food seeking, similarities and differences in mechanisms underlying reinstatement of food seeking versus drug seeking, and the degree to which the reinstatement procedure provides a suitable model for studying relapse in humans. We conclude by discussing implications for medication development and future research. We offer three tentative conclusions:
登录
查看更多内容
影响因子：
5.4
作者：
BINDRA, D
通讯作者：
BINDRA, D
影响因子：
3.4
作者：
Baker, DA;Tran-Nguyen, LTL;Neisewander, JL
通讯作者：
Neisewander, JL
影响因子：
5.3
作者：
Baptista, MAS;Martin-Fardon, R;Weiss, F
通讯作者：
Weiss, F
影响因子：
3.7
作者：
Beninger, RJ;Gerdjikov, TV
通讯作者：
Gerdjikov, TV
影响因子：
7.6
作者：
Anggadiredja, K;Nakamichi, M;Yamamoto, T
通讯作者：
Yamamoto, T