Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar
Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar
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DOI：
10.1021/np0605034
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发表时间：
2007-02-01
影响因子：
5.1
通讯作者：
Kingston, David G. I.
中科院分区：
文献类型：
--
作者：
Williams, Russell B.;Norris, Andrew;Kingston, David G. I.
通过生物测定引导的对Casearia nigrescens的细胞毒性叶和花提取物的分级分离，分离出四种新的克罗烷二萜类化合物，命名为caseanigrescens A-D（1-4）。这些化合物在CDCl 3中储存时水解为二醛。化合物1-4的结构使用1D和2D NMR光谱确定。所有四种化合物对A2780人卵巢癌细胞系显示出中等的细胞毒性，IC 50范围为0.83-1.4 μ M。
Bioassay-guided fractionation of the cytotoxic leaf and flower extract of Casearia nigrescens led to the isolation of four new clerodane diterpenoids, designated caseanigrescens A-D (1-4). These compounds were subject to hydrolysis to dialdehydes when stored in CDCl3. The structures of compounds 1-4 were determined using 1D and 2D NMR spectroscopy. All four compounds showed moderate cytotoxicity to the A2780 human ovarian cancer cell line, with an IC50 range of 0.83-1.4 mu M.