Matrix effect-free analytical methods for determination of perfluorinated carboxylic acids in environmental matrixes
Matrix effect-free analytical methods for determination of perfluorinated carboxylic acids in environmental matrixes
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DOI：
10.1021/ac0508090
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发表时间：
2005-10-01
影响因子：
7.4
通讯作者：
Buck, RC
中科院分区：
文献类型：
--
作者：
Powley, CR;George, SW;Buck, RC
全氟羧酸（PFCAs）是一种广泛存在于环境中的持久性化学物质。准确测定环境基质，特别是土壤，沉积物和污泥中的低水平，提出了重大的分析挑战。用于液相色谱-质谱分析的电喷雾接口的商业化促进了低水平的PFCAs分析，但由于基质抑制或增强而导致的定量分析问题仍然存在。本研究中描述的方法利用简单快速的样品纯化程序充分去除基质组分，因此共洗脱基质峰引起的误差可忽略不计，并且PFCA的回收率一致且可重复定量。固体样品（土壤和沉积物）和液体细菌污泥的提取物纯化使用分散固相萃取。回收率值通常在70 - 120%范围内，定量限为1 ppb。该方法利用了一种提取溶剂，以前显示释放和回收老化残留物的全氟辛烷磺酸。还提供并证明了使用两种前体产物离子的确证方法。
Perfluorocarboxylic acids (PFCAs) are persistent chemicals that have been found widely in the environment. Their accurate determination in environmental matrixes, particularly soil, sediment, and sludge, at low levels presents significant analytical challenges. The commercialization of electrospray interfaces for liquid chromatography-mass spectrometric analysis facilitated analysis of PFCAs at low levels, but issues with quantitative analysis due to matrix suppression or enhancement still persist. The methods described in this study utilize simple and rapid sample purification procedures to remove matrix components sufficiently so that errors due to coeluting matrix peaks are negligible and recoveries of PFCAs are consistently and reproducibly quantitative. Extracts from solid samples (soil and sediment) and liquid bacterial sludge are purified using dispersive solid-phase extraction. Recovery values generally are in the 70 - 120% range, with limits of quantitation of 1 ppb. The method utilizes an extraction solvent previously shown to release and recover aged residues of PFCAs. A confirmatory method using two precursor to product ions is also provided and demonstrated.