Cardiopulmonary hospitalizations during influenza season in adults and adolescents with advanced HIV infection
Cardiopulmonary hospitalizations during influenza season in adults and adolescents with advanced HIV infection
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DOI：
10.1097/00126334-200311010-00008
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发表时间：
2003-11-01
影响因子：
3.6
通讯作者：
Griffin, MR
中科院分区：
文献类型：
--
作者：
Neuzil, KM;Coffey, CS;Griffin, MR
自采用高效抗逆转录病毒疗法（HAART）以来，流感在艾滋病毒感染者住院和死亡中的病因作用尚不清楚。对1995年至1999年参加田纳西州医疗补助计划的所有15至50岁的艾滋病或晚期HIV感染者进行了回顾性队列研究，代表了7368人年的随访。根据当地病毒监测确定流感季节，并测量全年因急性心肺原因和任何原因导致的死亡而住院的情况。从1995年到1999年，艾滋病毒感染者的心肺住院率下降了53%，死亡率下降了77%。引入HAART后，1995年流感导致的住院率为48/1000人（95%置信区间[CI]：16-91），1996年至1999年期间为5/1000人（95% CI：-0.5-11）。在HAART后时代，HIV感染患者的流感相关住院率下降。然而，这一比例与其他建议每年接种流感疫苗的高危人群的比例相当。
The etiologic role of influenza in hospitalizations and deaths among persons infected with HIV since the introduction of highly active antiretroviral therapy (HAART) is not known. A retrospective cohort study was performed of all persons aged 15 to 50 years with AIDS or advanced HIV infection enrolled in the Tennessee Medicaid program from 1995 through 1999, representing 7368 person-years of follow-up. The influenza season was defined based on local virus surveillance, and hospitalizations were measured for acute cardiopulmonary causes and deaths from any cause throughout the year. From 1995 through 1999, cardiopulmonary hospitalization rates in HIV-infected patients declined by 53% and death rates declined by 77%. The influenza-attributable hospitalization rate was 48 (95% confidence interval [CI]: 16-91) per 1000 persons in 1995 and 5 (95% CI: -0.5-11) per 1000 persons per year during 1996 through 1999, after the introduction of HAART. Influenza-associated hospitalizations have declined in patients with HIV infection in the post-HAART era. Rates remain comparable to rates in other high-risk groups for which annual influenza vaccination is recommended, however.