Cylindrospermopsin in water supply reservoirs in Brazil determined by immunochemical and molecular methods.
Cylindrospermopsin in water supply reservoirs in Brazil determined by immunochemical and molecular methods.
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DOI：
10.4236/jwarp.2011.36044
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
do N. Moura, A.
中科院分区：
文献类型：
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作者：
Bittencourt-Oliveira, M. do C.;Piccin-Santos, V.;do N. Moura, A.
据报道，巴西和南美洲的供水水库中首次发现了圆柱精蛋白（CYN）。 CYN 是一种强效肝毒性生物碱，与人类疾病的爆发有关。我们使用分子和免疫学技术在巴西东北部的不同水源中检测到了 CYN。毒素浓度最高的地方是 Jucazinho 水库，其浮游植物中含有可能产生 CYN 的 Cylindrospermopsis raciborskii 和 Sphaerospermopsis aphanizomenoides（以前称为 Aphanizomenon aphanizomenoides）。在所有分析的样品中都发现了与产生 CYN 的能力直接相关的聚酮合酶 (PKS) 和肽合成酶 (PS)。本研究的结果强调需要改进对用于饮用和娱乐的水体中 CYN 的监测，以避免人群接触这种毒素。
It is reported for the first time in Brazil and South America the presence of cylindrospermopsin (CYN) in water supply reservoirs. CYN is a powerful hepatotoxic alkaloid implicated in outbreaks of human sicknesses. We detected CYN in different sources of water in Northeastern Brazil using molecular and immunological techniques. The highest concentrations of toxin occurred in the Jucazinho reservoir with the phytoplankton containing the potentially CYN-producing Cylindrospermopsis raciborskii and Sphaerospermopsis aphanizomenoides (previously known as Aphanizomenon aphanizomenoides). The polyketide synthase (PKS) and peptide synthetase (PS), which are directly related to the ability to produce CYN, were found in all the analyzed samples. The result of the present study emphasizes the need to improve monitoring of CYN in water bodies used for drinking and recreation, in order to avoid exposure of human populations to this toxin.