Mild versus severe COVID-19: Laboratory markers
Mild versus severe COVID-19: Laboratory markers
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DOI：
10.1016/j.ijid.2020.04.061
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发表时间：
2020-06-01
影响因子：
8.4
通讯作者：
Meyer, Christian G.
中科院分区：
文献类型：
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作者：
Velavan, Thirumalaisamy P.;Meyer, Christian G.
COVID-19患者的数量在全球范围内急剧增加。重症监护室（ICU）的治疗已成为一个重大挑战;因此，早期识别严重的形式是绝对必要的，以及时分流的病人。虽然COVID-19患者的临床状态，特别是外周血氧饱和度（SpO 2）水平和并发症在很大程度上决定了他们是否需要进入ICU，但几个实验室参数可能有助于评估疾病严重程度。临床医生应考虑低淋巴细胞计数以及CRP、D-二聚体、铁蛋白、心肌肌钙蛋白和IL-6的血清水平，这些可用于风险分层，以预测住院患者的严重和致命性COVID-19。如果这些参数中的一些或全部改变，则疾病的过程更可能是不利的。(C)2020作者（S）由爱思唯尔有限公司代表国际传染病学会出版。
The number of COVID-19 patients is dramatically increasing worldwide. Treatment in intensive care units (ICU) has become a major challenge; therefore, early recognition of severe forms is absolutely essential for timely triaging of patients. While the clinical status, in particular peripheral oxygen saturation (SpO2) levels, and concurrent comorbidities of COVID-19 patients largely determine the need for their admittance to ICUs, several laboratory parameters may facilitate the assessment of disease severity. Clinicians should consider low lymphocyte count as well as the serum levels of CRP, D-dimers, ferritin, cardiac troponin and IL-6, which may be used in risk stratification to predict severe and fatal COVID-19 in hospitalised patients. It is more likely that the course of the disease will be unfavourable if some or all of these parameters are altered. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.