Maternal depression and risk for postpartum complications: role of prenatal corticotropin-releasing hormone and interleukin-1 receptor antagonist.
Maternal depression and risk for postpartum complications: role of prenatal corticotropin-releasing hormone and interleukin-1 receptor antagonist.
复制标题
产妇抑郁症和产后并发症的风险：产前促肾上腺皮质激素释放激素和白介素 1 受体拮抗剂的作用。
DOI：
10.1080/08964289909595741
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Chrousos,GP
中科院分区：
文献类型：
--
作者：
Schmeelk,KH;Granger,DA;Susman,EJ;Chrousos,GP
对58名13岁至19岁的健康青少年妊娠进行跟踪调查，以探讨抑郁症状、促肾上腺皮质激素释放激素(CRH)、白细胞介素Iβ(IL-1β)和IL-1受体拮抗剂(IL-1ra)之间的关系，以作为预测母婴结局的可能指标。监测孕妇在妊娠、分娩、分娩和产后期间的心理适应和内科并发症。测定孕期血浆促肾上腺皮质激素释放激素、白介素1β和白介素1ra。在妊娠期间，发现母亲抑郁的症状与较低的CRH水平有关；较低的CRH水平与较低的IL-1ra水平有关。此外，IL-1ra水平越低，分娩后产妇并发症的发生率就越高。仅在4名母亲中检测到的IL-1β与任何预测因素或结果衡量标准无关。在妊娠期间，CRH可以诱导循环中的细胞因子抑制物，而不会显著影响细胞因子的产生或合成。孕期抑郁的母亲症状可能会减弱CRH和IL-1ra之间的联系。
The pregnancies of 58 healthy adolescents (ages 13 to 19 years) were followed to examine links between symptoms of depression, corticotropin-releasing hormone (CRH), interleukin-Iβ, (IL-1β), and IL-1 receptor antagonist (IL-1ra) as possible predictors of maternal and infant outcomes. Maternal psychological adjustment and medical complications during gestation, labor, delivery, and the postpartum period were monitored. Plasma samples collected during gestation were assayed for CRH, IL-1β, and IL-1ra. During gestation, symptoms of maternal depression were found to be associated with lower levels of CRH; lower levels of CRH were associated with lower levels of IL-1ra. In addition, lower levels of IL-1ra predicted higher rates of maternal complications after childbirth. IL-1β, detected in only 4 mothers, was not associated with any predictor or outcome measures. During gestation, CRH may induce circulating cytokine inhibitors without significantly affecting cytokine production or synthesis. Maternal symptoms of depression during gestation may attenuate the association between CRH and IL-1ra.