Health-related quality of life and utilities in primary-care patients with generalized anxiety disorder
Health-related quality of life and utilities in primary-care patients with generalized anxiety disorder
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DOI：
10.1007/s11136-008-9406-6
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发表时间：
2008-12-01
影响因子：
3.5
通讯作者：
Feeny, David
中科院分区：
文献类型：
--
作者：
Revicki, Dennis A.;Brandenburg, Nancy;Feeny, David
广泛性焦虑症(GAD)是一种常见的疾病，对患者的健康相关生活质量(HRQL)和残疾有显著影响。本研究评估了GAD和焦虑症状严重程度对GAD患者HRQL的影响。临床评估包括汉密尔顿焦虑量表(HAM-A)、GAD问卷-IV(GAD-Q-IV)和患者健康问卷抑郁模块(PHQ)。采用简式生活质量与满意度问卷(Q-LES-Q-SF)、Sheehan残障量表(SDS)、SF-12健康调查问卷(SF-6D)和健康效用指数(HUI2、HUI3)对297例患者(72%)进行评估，样本平均+/-标准差(SD)为47.6+/-13.7岁。在基线时，HAM-A的平均得分为16.8+/-7.6(表明存在中度焦虑症状)。焦虑、抑郁症状与心理成分总分、Q-LES-Q-SF、抑郁自评量表、SF-6D、HUI2、HUI3分呈显著正相关(P均<0.001)。焦虑严重程度组的平均高质量生活质量和所有基于偏好的测量结果差异显著(均P<；0.001)。焦虑和抑郁症状显著预测HRQL和基于偏好的评分(R2值在0.22到0.57之间)。GAD患者报告的焦虑症状导致HRQL和功能结果的显著损害。
Generalized anxiety disorder (GAD) is prevalent and significantly impacts patient health-related quality of life (HRQL) and disability.This study evaluated the effect of GAD and anxiety symptom severity on the HRQL of primary-care patients with GAD.Patients 18 years or older with GAD were recruited from an integrated health care delivery system. Clinical assessments included the Hamilton Anxiety Rating Scale (HAM-A), GAD Questionnaire-IV (GAD-Q-IV), and the Patient Health Questionnaire depression module (PHQ). HRQL was assessed by the Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF), Sheehan Disability Scale (SDS), SF-12 Health Survey (SF-6D), and the Health Utilities Index (HUI2, HUI3).The sample included 297 patients, 72% women with mean +/- standard deviation (SD) age of 47.6 +/- 13.7 years. At baseline, the mean HAM-A score was 16.8 +/- 7.6 (suggesting the presence of moderate anxiety symptoms). Anxiety and depression symptoms were significantly correlated with mental component summary (MCS), Q-LES-Q-SF, SDS, SF-6D, HUI2, and HUI3 scores (all P < 0.001). The mean HRQL and all of the preference-based measures varied significantly by anxiety severity groups (all P < 0.001). Anxiety and depression symptoms significantly predicted HRQL and preference-based scores (R-2 values ranged from 0.22 to 0.57).Anxiety symptoms reported by GAD patients resulted in significant impairment to HRQL and functional outcomes.