Migration of bisphenol-A diglycidyl ether (BADGE) and its reaction products in canned foods
Migration of bisphenol-A diglycidyl ether (BADGE) and its reaction products in canned foods
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DOI：
10.1080/026520300750038126
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发表时间：
2000-11-01
影响因子：
2.9
通讯作者：
Oskarsson, A
中科院分区：
文献类型：
--
作者：
Hammarling, L;Gustavsson, H;Oskarsson, A
双酚 A 二缩水甘油醚 (BADGE) 用作罐头涂料的添加剂或起始剂。有机溶胶（PVC 基）清漆中存在盐酸会导致形成 BADGE 氯羟基化合物。这些化合物以及 BADGE 本身可能会迁移到保存的食品中，并引起毒理学关注。在本次调查中，通过高效液相色谱法和荧光检测法测定了 30 个品牌的各种罐头食品中 BADGE 和氯羟基化合物（BADGE.HCl 和 BADGE.2HCl）的存在。食品中发现 BADGE 含量高达 5.1 毫克/千克，且仅存在于漆中含有 BADGE.HCl 和 BADGE.2HCl 的罐装食品中。 BADGE 在油浸鱼和番茄酱鱼中均被发现，但在脂肪食品中含量最高。徽章。 HCl 和 BADGE.2HCl 的浓度分别高达 2.4 mg/kg 和 8.3 mg/kg。与 BADGE 不同，BADGE.2HCl 在油浸鱼和番茄酱鱼中的浓度相似。在水性和酸性食品中，BADGE 很容易水解成单水解和二水解产物（BADGE.H2O 和 BADGE.2H(2)O）。在本研究中，任何食品样品中均未发现 BADGE.H2O，而 BADGE.2H(2)O 的含量高达 2.6 毫克/千克。欧盟委员会食品科学委员会(SCF)提出1mg/kg食品的限制限量应包括BADGE本身和BADGE.H2O、BADGE。 HCl、BADGE.2HCl 和 BADGE。 HCl.H2O。目前的结果表明 BADGE 的迁移。 HCl 和 BADGE.2HCl 是几乎没有毒性数据的化合物，比 BADGE.H2O 和 BADGE.2H(2)O 意味着更大的问题。
Bisphenol-A diglycidyl ether (BADGE) is used as an additive or starting agent in coatings for cans. The presence of hydrochloric acid in the organosol (PVC-based) lacquers results in formation of chlorohydroxy compounds of BADGE. These compounds, as well as BADGE itself, are potential migrants into the preserved food and are of toxicological concern. In the present investigation the presence of BADGE and the chlorohydroxy compounds (BADGE.HCl and BADGE.2HCl) in various kinds of canned foods from 30 brands have been determined by HPLC with fluorescence detection. BADGE was found in levels up to 5.1 mg/kg in the food and only in food from cans containing BADGE.HCl and BADGE.2HCl in the lacquers. BADGE was found both in fish in oil and in fish in tomato sauce, however, the highest amounts were found in the fatty foodstuffs. BADGE. HCl and BADGE.2HCl were found in concentrations up to 2.4 mg/kg and 8.3 mg/kg, respectively. Unlike BADGE, BADGE.2HCl was found in similar concentrations in fish in oil and in fish in tomato sauce. In aqueous and acidic foodstuffs BADGE readily hydrolyses into mono- and dihydrolysed products (BADGE.H2O and BADGE.2H(2)O). In this study BADGE.H2O was not found in any food sample, whereas BADGE.2H(2)O was found in levels up to 2.6 mg/kg. The Scientific Committee for Food (SCF) of the European Commission has proposed that a limit of restriction of 1 mg/ kg food shall include BADGE itself and BADGE.H2O, BADGE. HCl, BADGE.2HCl and BADGE. HCL.H2O. The present results indicate that the migration of BADGE. HCl and BADGE.2HCl, compounds with almost no data on toxicity, implies a greater problem than BADGE.H2O and BADGE.2H(2)O.