Polarimetric analysis of the human cornea measured by polarization-sensitive optical coherence tomography
Polarimetric analysis of the human cornea measured by polarization-sensitive optical coherence tomography
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DOI：
10.1117/1.3486540
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发表时间：
2010-09-01
影响因子：
3.5
通讯作者：
Arce-Diego, Jose Luis
中科院分区：
文献类型：
--
作者：
Fanjul-Velez, Felix;Pircher, Michael;Arce-Diego, Jose Luis
角膜旋光测量已成为多篇论文的主题。偏振敏感光学相干断层扫描 (PS-OCT)、扫描激光偏振测定法或偏振显微镜等技术的结果是矛盾的。一些研究提出了类似双轴的双折射图案，而另一些研究则假设双折射在角膜周边生长。人们提出了几种理论方法来解释这些测量结果，但它们通常缺乏准确性，也缺乏对组织上非正态发生率的充分考虑。我们分析了 PS-OCT 测量的角膜偏振效应。获取人角膜的体内和体外 PS-OCT 图像。 PS-OCT 测量结果显然与类双轴双折射图案不一致。我们提出了一种基于应用于多层系统的扩展琼斯矩阵形式的人类角膜偏振模型。我们还应用庞加莱等价定理来提取光轴方向和双折射。结果表明，对于由圆形和放射状原纤维交替组成的原纤维取向图案，在角膜中心处具有类双轴双折射，并且在角膜周边存在几乎圆形对称的高双折射区域。该模型可用于诊断角膜疾病或视网膜偏振成像中的角膜补偿。 (C) 2010 年光电仪器工程师协会。 [DOI：10.1117/1.3486540]
Corneal polarimetry measurement has been the object of several papers. The results of techniques like polarization-sensitive optical coherence tomography (PS-OCT), scanning laser polarimetry, or polarization microscopy are contradictory. Some studies propose a biaxial-like birefringence pattern, while others postulate that birefringence grows at corneal periphery. Several theoretical approaches were proposed for the interpretation of these measurements, but they usually lack accuracy and an adequate consideration of the nonnormal incidence on the tissue. We analyze corneal polarization effects measured by PS-OCT. In vivo and in vitro PS-OCT images of the human cornea are acquired. PS-OCT measurements are apparently not in agreement with the biaxial-like birefringence pattern. We present a polarimetric model of the human cornea based on the extended Jones matrix formalism applied to multilayered systems. We also apply the Poincare equivalence theorem to extract optic axis orientation and birefringence. The results show that for a fibrils orientation pattern composed by alternating circular and radial fibrils, the birefringence is biaxial-like at the corneal center, and there is an almost circularly symmetric high-birefringence area at corneal periphery. The model could be useful for diagnosis of corneal diseases or corneal compensation in retinal polarimetric imaging. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3486540]