Modifiable risk factors and erectile dysfunction: Can lifestyle changes modify risk?
Modifiable risk factors and erectile dysfunction: Can lifestyle changes modify risk?
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DOI：
10.1016/s0090-4295(00)00614-2
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发表时间：
2000-08-01
期刊：
影响因子：
2.1
通讯作者：
McKinlay, JB
中科院分区：
文献类型：
--
作者：
Derby, CA;Mohr, BA;McKinlay, JB
目标.前瞻性研究吸烟、大量饮酒、久坐不动的生活方式和肥胖是否与勃起功能障碍的风险相关。收集数据作为队列研究的一部分，随机抽取40至70岁的男性样本，从马萨诸塞州波士顿都会区的街道列表中选出。在1987年至1989年的基线和1156名男子在1995年至1997年的后续（平均随访8.8年）完成了家庭访谈。分析包括593名基线时没有勃起功能障碍的男性，他们没有前列腺癌，也没有接受过心脏病或糖尿病治疗。中度至完全性勃起功能障碍的发病率是通过对自我管理的性功能问卷调查结果进行判别分析来确定的，肥胖状态与勃起功能障碍相关（P = 0.006），无论后续的体重减轻，基线肥胖预测的风险较高。体力活动状态与勃起功能障碍相关（P = 0.01），保持久坐的男性风险最高，保持活跃或开始体力活动的男性风险最低。吸烟和饮酒的变化与勃起功能障碍的发生率无关（P > 0.3）。中年改变可能为时已晚，无法逆转吸烟、肥胖和饮酒对勃起功能障碍的影响。相反，即使在中年开始，体力活动也可以降低勃起功能障碍的风险。早期采用健康的生活方式可能是减少勃起功能障碍对老年男性健康和福祉的负担的最佳方法。泌尿学56：302-306，2000年。(C)2000年，Elsevier Science Inc.
Objectives. To prospectively examine whether changes in smoking, heavy alcohol consumption, sedentary lifestyle, and obesity are associated with the risk of erectile dysfunction.Methods. Data were collected as part of a cohort study of a random sample of men 40 to 70 years old, selected from street listings in the Boston Metropolitan Area, Massachusetts. In-home interviews were completed by 1709 men at baseline in 1987 to 1989 and 1156 men at follow-up in 1995 to 1997 (average follow-up 8.8 years). Analyses included 593 men without erectile dysfunction at baseline, who were free of prostate cancer, and had not been treated for heart disease or diabetes. The incidence of moderate to complete erectile dysfunction was determined by discriminant analysis of responses to a self-administered sexual function questionnaire.Results, Obesity status was associated with erectile dysfunction (P = 0.006), with baseline obesity predicting a higher risk regardless of follow-up weight loss. Physical activity status was associated with erectile dysfunction (P = 0.01), with the highest risk among men who remained sedentary and the lowest among those who remained active or initiated physical activity. Changes in smoking and alcohol consumption were not associated with the incidence of erectile dysfunction (P > 0.3).Conclusions. Midlife changes may be too late to reverse the effects of smoking, obesity, and alcohol consumption on erectile dysfunction. In contrast, physical activity may reduce the risk of erectile dysfunction even if initiated in midlife. Early adoption of healthy lifestyles may be the best approach to reducing the burden of erectile dysfunction on the health and well-being of older men. UROLOGY 56: 302-306, 2000. (C) 2000, Elsevier Science Inc.