Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD
Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD
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DOI：
10.1002/ana.20417
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发表时间：
2005-04-01
影响因子：
11.2
通讯作者：
Chinnery, PF
中科院分区：
文献类型：
--
作者：
Pyle, A;Foltynie, T;Chinnery, PF
越来越多的证据表明，线粒体DNA的遗传变异在特发性帕金森病的病因中起着重要作用。我们测定了455名帕金森病患者、185名阿尔茨海默病患者和447名健康英国对照者的线粒体DNA单倍群。UKJT单倍群粉尘与帕金森病人群归因风险降低22%相关。单个单倍群或UKJT簇与阿尔茨海默病之间没有关联，证实了与帕金森病的关联是疾病特异性的，而不是在所有神经退行性疾病中看到的普遍效应。
There is increasing evidence that genetic variants of mitochondrial DNA have an important role in the cause of idiopathic Parkinson's disease. We determined the mitochondrial DNA haplogroup of 455 Parkinson's disease cases, 185 Alzheimer's disease cases, and 447 healthy English control subjects. The UKJT haplogroup duster was associated with a 22% reduction in population-attributable risk for Parkinson's disease. There was no association between individual haplogroups or the UKJT cluster and Alzheimer's disease, confirming that the association with Parkinson's disease was disease specific and not a general effect seen in all neurodegenerative diseases.