Alterations of ATP levels and of energy parameters in the blood of alcoholic and nonalcoholic patients with liver damage.
Alterations of ATP levels and of energy parameters in the blood of alcoholic and nonalcoholic patients with liver damage.
复制标题
患有肝损伤的酒精和非酒精患者血液中 ATP 水平和能量参数的变化。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
V. Chagoya de Sánchez
中科院分区：
文献类型：
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作者：
R. Hernández;W. Glender;M. Díaz;J. Suárez;J. Lozano;V. Chagoya de Sánchez
测定酒精性和非酒精性肝病患者的血液腺嘌呤核苷酸。他们包括酒精性肝炎（AH）、酒精性肝硬化（ALC）、非酒精性肝硬化（NALC）和阿米巴肝脓肿（ALA）患者（28 名患者）。 AH 组和肝硬化组的血液 ATP 水平分别下降 28% 至 39%（p 小于 0.05），而 ALA 组的血液 ATP 水平没有检测到显着变化。尽管 AH、ALC 和 NALC 组的血液总腺嘌呤核苷酸显着减少，但 AH 患者的能量关系保持在正常范围内。另一方面，肝硬化组，无论其病因如何，都未能在血液中维持足够的 ATP/ADP 比率、能量电荷和磷酸化电位，这表明其血细胞中的能量可用性降低。然而，这些影响的机制仍有待阐明，受损的肝脏无法向肝外组织供应嘌呤可能是改变血液能量参数的主要事件。
Blood adenine nucleotides were determined in patients with alcoholic and non-alcoholic liver diseases. They included patients with alcoholic hepatitis (AH), alcoholic liver cirrhosis (ALC), non-alcoholic liver cirrhosis (NALC), and amoebic liver abscess (ALA) (28 patients). A decrease of 28% to 39% in blood ATP levels was observed among the patients with AH and the cirrhotic groups, respectively (p less than 0.05), whereas no significant changes in blood ATP levels were detected in the ALA group. Although total blood adenine nucleotides were significantly diminished in AH, ALC, and NALC groups, the AH patients retained their energy relationships within normal range. On the other hand, the cirrhotic groups, independently of their etiology, failed to maintain an adequate ATP/ADP ratio, energy charge, and phosphorylation potential in the blood, suggesting a decreased energy availability in their blood cells. Nevertheless, the mechanism involved in these effects remains to be elucidated, a failure of the damaged liver to supply purines to extra-hepatic tissues might be a major event altering the blood energy parameters.