Environmental carbon monoxide level is associated with the level of high-sensitivity C-reactive protein in peritoneal dialysis patients.
Environmental carbon monoxide level is associated with the level of high-sensitivity C-reactive protein in peritoneal dialysis patients.
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DOI：
10.1097/md.0000000000000181
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发表时间：
2014-11
期刊：
影响因子：
1.6
通讯作者：
Su YJ
中科院分区：
文献类型：
--
作者：
Huang WH;Yen TH;Chan MJ;Su YJ
炎症在腹膜透析（PD）患者中非常普遍。高敏C反应蛋白（hs-CRP）是临床医学中最广泛使用的炎症标志物，与PD患者的死亡率相关。空气污染与全身炎症有关。这项横断面研究的目的是评估空气污染物和其他临床变量对 PD 患者 hs-CRP 值的影响。我们总共招募了 175 名接受连续门诊 PD 或自动 PD 至少 4 个月并定期随访的患者。台湾各地患者居住区附近或区内的 27 个监测站网络记录了空气污染水平。包括空气动力学直径<10和<2.5μm的颗粒物（PM10和PM2.5）、二氧化硫（SO2）、二氧化氮（NO2）、一氧化碳（CO）和臭氧（O3）的12个月平均浓度。在逐步线性回归中，调整相关因素后，白细胞计数（β：0.27，95%置信区间[CI][0.71，2.11]）和CO水平（β：0.17，95% CI [2.5，21.32]）与hs-CRP和血清白蛋白水平呈正相关（β：-0.25，95% CI [-13.69， -3.96]）和标准化蛋白氮外观（β：-0.18，95% CI [-17.7，-2.51]）与 hs-CRP 呈负相关。然而，血清硫酸吲哚酚和硫酸对甲苯酯水平与hs-CRP无显着相关性（P > 0.05）。在PD患者中，环境CO水平与hs-CRP水平呈正相关。
Inflammation is highly prevalent among peritoneal dialysis (PD) patients. High-sensitivity C-reactive protein (hs-CRP) is the most widely used inflammatory marker in clinical medicine and is correlated with mortality in PD patients. Air pollution is associated with systemic inflammation. The aim of this cross-sectional study was to assess the role of air pollutants and other clinical variables on hs-CRP values in PD patients. We recruited a total of 175 patients who had been undergoing continuous ambulatory PD or automated PD for at least 4 months and regularly followed up. Air pollution levels were recorded by a network of 27 monitoring stations near or in the patients’ living areas throughout Taiwan. The 12-month average concentrations of particulate matter (PM) with an aerodynamic diameter of <10 and <2.5 μm (PM10 and PM2.5), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3) were included. In stepwise linear regression, after adjustment for related factors, white blood cell count (β: 0.27, 95% confidence interval [CI] [0.71, 2.11]) and CO level (β: 0.17, 95% CI [2.5, 21.32]) were positively associated with hs-CRP and serum albumin levels (β: −0.25, 95% CI [−13.69, −3.96]) and normalized protein nitrogen appearance (β: −0.18, 95% CI [−17.7, −2.51]) was negatively associated with hs-CRP. However, serum indoxyl sulfate and p-cresyl sulfate levels were not significantly associated with hs-CRP (P > 0.05). In PD patients, the environmental CO level was positively correlated with hs-CRP level.