Toward a biochemical classification of depressive disorders--VIII. Platelet monoamine oxidase activity in subtypes of depressions.
Toward a biochemical classification of depressive disorders--VIII. Platelet monoamine oxidase activity in subtypes of depressions.
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抑郁症的生化分类——VIII。
DOI：
10.1016/0022-3956(85)90072-x
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发表时间：
1985
影响因子：
4.8
通讯作者：
Schildkraut,JJ
中科院分区：
文献类型：
--
作者：
Samson,JA;Gudeman,JE;Schatzberg,AF;Kizuka,PP;Orsulak,PJ;Cole,JO;Schildkraut,JJ
本文对77例抑郁症患者（男40例，女37例）和28例正常人（男14例，女14例）进行了血小板单胺氧化酶（MAO）活性测定。在一个四步数据分析程序中，将患者在越来越具体的诊断分组中进行比较。在步骤1中，将抑郁症患者总样本中的MAO活性与对照受试者进行比较。在第2步中，将单相抑郁患者与双相（双相I和双相II）抑郁患者进行比较。在第3步中，比较了具有和不具有典型特征的单相抑郁患者。在第4步中，将非典型单极患者和非典型双相患者分为符合RDC明确内源性抑郁标准的患者和不符合标准的患者;结果表明，非典型单相内源性抑郁症患者的血小板单胺氧化酶活性显著高于非典型双相内源性抑郁症患者和非典型单相其他抑郁症患者患者此外，在单相和双相抑郁患者中，明确的内源性抑郁综合征的存在与更大的总体症状严重程度相关。研究结果进行了讨论，相对于在以往的研究中报告的抑郁症患者的单胺氧化酶活性的相互矛盾的结果。
Platelet monoamine oxidase (MAO) activity was examined in 77 depressed patients (40 males and 37 females) and 28 controls (14 males and 14 females). Patients were compared across increasingly specific diagnostic groupings in a four-step data analytic procedure. In step 1, MAO activity in the total sample of depressed patients was compared with that of control subjects. In step 2, Unipolar depressed patients were compared with Bipolar (Bipolar I and Bipolar II) depressed patients. In step 3, Unipolar depressed patients with and without schizotypal features were compared. In step 4, both the nonschizotypal Unipolar patients and nonschizotypal Bipolar patients were separated into those who met RDC criteria for a definite Endogenous depression and those who did not; and platelet MAO activity was compared in the resulting four groups.Results indicated significantly higher platelet MAO activity in nonschizotypal Unipolar Endogenous depressed patients than in nonschizotypal Bipolar Endogenous depressed patients or nonschizotypal Unipolar Other patients. In addition, the presence of a definite Endogenous depressive syndrome was associated with greater overall symptom severity in both Unipolar and Bipolar depressed patients. Findings are discussed with respect to the conflicting results reported in previous studies of MAO activity in patients with depressive disorders.