Spiroxins, DNA cleaving antitumor antibiotics from a marine-derived fungus
Spiroxins, DNA cleaving antitumor antibiotics from a marine-derived fungus
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DOI：
10.1016/s0040-4039(99)00242-7
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发表时间：
1999-03-26
影响因子：
1.8
通讯作者：
Carter, GT
中科院分区：
文献类型：
--
作者：
McDonald, LA;Abbanat, DR;Carter, GT
The spiroxins (1-5) were purified from the culture extract of a marine-derived fungus. Their unique bisnaphthospiroketal structures were established by NMR spectroscopy. In addition to cytotoxicity, these compounds showed antibiotic activity and were active in a mouse xenograft model against human ovarian carcinoma. The mechanism of action of these compounds was shown to be due, in part, to their effect on DNA. (C) 1999 Elsevier Science Ltd. All rights reserved.
