Passive transfer of maternal immunoglobulin isotype antibodies against tetanus and influenza and their effect on the response of foals to vaccination.
Passive transfer of maternal immunoglobulin isotype antibodies against tetanus and influenza and their effect on the response of foals to vaccination.
复制标题
抗破伤风和流感的母体免疫球蛋白同种型抗体的被动转移及其对马驹疫苗接种反应的影响。
DOI：
10.2746/042516401776249435
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发表时间：
2010
影响因子：
2.2
通讯作者：
D. Lunn
中科院分区：
文献类型：
--
作者：
W. D. Wilson;J. Mihalyi;S. Hussey;D. Lunn
Ig G亚型的流感和破伤风特异性抗体通过初乳阳性地传播给马驹，并抑制它们对灭活流感疫苗和破伤风类毒素的反应。在孕期最后2个月加强免疫的母马吸血后血清标本中，检测到高滴度的IggA和Ig Gb亚型流感抗体和IggA、Ig Gb和Ig G(T)亚型的破伤风抗体。此后，滴度呈指数下降，但在26周龄的所有马驹中仍可检测到滴度，无论它们是否在26周龄之前接种过疫苗。平均值+/-S.E.流感免疫球蛋白抗体下降的半衰期(27.0±-2.3d)明显短于流感免疫球蛋白抗体(39.1+/-2.7d；P<；0.005)。破伤风Igga和IgGb抗体半衰期分别为28.8+/-3.0天和34.8+/-5.1天。在吸食后的样本中，破伤风抗体(T)的滴度显著高于流感(T)抗体的滴度，并一直保持到26周，半衰期约为35天。吸吮后的破伤风和流感同型抗体滴度很低，并迅速下降到无法检测到的水平。接种2剂破伤风类毒素、甲型流感灭活疫苗和甲型流感灭活疫苗后，1周龄仔猪的IggA、Ig Gb和Ig G(T)亚型抗体滴度显著升高，而Ig A抗体的滴度无明显增加。破伤风Igga、Ig Gb和Ig G(T)亚型对一剂疫苗的反应也很强，3周后第二剂疫苗的效价显著升高，但没有表现出破伤风IgA抗体滴度的增加。6月龄小马驹的流感和破伤风Igga、Ig Gb和Ig G(T)亚型反应与1岁龄小马驹相同，但滴度普遍较低。相比之下，3个月大的小马驹在接种2剂疫苗后，无论是流感还是破伤风免疫球蛋白亚型的滴度都没有表现出增加，通常需要额外接种1-3剂疫苗才能达到与1岁大的马驹在接种2剂疫苗后所达到的滴度相似的水平。基于母体抗体对小马驹对破伤风类毒素和灭活流感抗原的反应有显著的抑制作用，建议接种疫苗的母马所生小马驹的初级免疫接种不应在6个月前开始。
Influenza and tetanus-specific antibodies of the IgG sub-isotypes are posively transferred to foals via colostrum and inhibit their response to inactivated influenza vaccines and tetanus toxoid. High titres of influenza antibodies of IgGa and IgGb subisotypes and tetanus antibodies of the IgGa, IgGb and IgG(T) subisotypes were detected in postsucking serum samples collected from foals born to mares that had received booster doses of multicomponent vaccines during the last 2 months of gestation. Thereafter, titres declined in an exponential manner but were still detectable in all foals at age 26 weeks, regardless of whether they had been vaccinated prior to age 26 weeks. Mean +/- s.e. half-life of decline of influenza IgGa antibodies (27.0 +/- 2.3 days) was significantly shorter than that of influenza IgGb antibodies (39.1 +/- 2.7 days; P<0.005). Tetanus IgGa and IgGb antibodies declined with half-lives of 28.8 +/- 3.0 and 34.8 +/- 5.1 days, respectively. Titres of tetanus IgG(T) antibodies were substantially higher than those of influenza IgG(T) antibodies in postsucking samples and remained so through age 26 weeks, declining with a half-life of approximately 35 days. Postsucking titres of tetanus and influenza antibodies of the IgA isotype were low and declined rapidly to undetectable levels. Yearlings showed significant increases in titre of influenza IgGa, IgGb and IgG(T) subisotype antibodies but no increase in influenza IgA antibodies in response to 2 doses of multicomponent vaccines containing tetanus toxoid and inactivated influenza A-1 and A-2 antigens. Yearlings also showed strong tetanus IgGa, IgGb and IgG(T) subisotype responses to one dose of vaccine and a substantial further rise in titre in response to administration of a second dose 3 weeks later, but failed to show an increase in titre of tetanus IgA antibodies. The influenza and tetanus IgGa, IgGb and IgG(T) subisotype responses of 6-month-old foals to vaccination followed the same pattern as those shown by yearlings but titres were generally lower. In contrast, 3-month-old foals failed to show increases in titre of either influenza or tetanus IgG subisotypes in response to 2 doses of vaccine and generally needed 1-3 additional booster doses of vaccine to achieve titres similar to those achieved by yearlings after 2 doses. Based on the finding that maternal antibodies exert a significant inhibitory effect on the response of foals to tetanus toxoid and inactivated influenza antigens, it is recommended that primary immunisation of foals born to vaccinated mares should not commence before age 6 months.