CORRELATION BETWEEN SECRETOR STATUS AND OCCURRENCE OF 2'-FUCOSYLLACTOSE IN HUMAN MILK
CORRELATION BETWEEN SECRETOR STATUS AND OCCURRENCE OF 2'-FUCOSYLLACTOSE IN HUMAN MILK
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DOI：
10.1016/0006-291x(67)90404-4
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发表时间：
1967-01-01
影响因子：
3.1
通讯作者：
GINSBURG, V
中科院分区：
文献类型：
--
作者：
GROLLMAN, EF;GINSBURG, V
分娩后1天至8周的妇女，唾液中有6种血型物质为非分泌型，其中A型和O型各3种，分泌A、H或B、H或H物质各2种，其中A型3种，B型2种，O型1种。在乳汁或初乳中，总己糖是正常的，在12名妇女之间的范围为32至96 mg/ml，但是对于分泌型的2 '-岩藻糖基乳糖为0.24至0.46 mg/ml，而在非分泌型中没有检测到。1955，88，1135），2 '-岩藻糖基-乳糖的存在与血型无关，并支持Watkins和Morgan的假设（Vox San-guinis，1959，4，97）和沃特金斯（Watkins）（Science，1966，152，172），H基因负责将莱亚转化为Leb物质和产生H物质所必需的岩藻糖基转移酶，后来转化为A或B物质，并且其在非分泌型中的缺失允许分泌莱亚物质，而不管血型如何。M. S.
Women 1 day to 8 weeks after parturition were 6 non-secretors of blood-group substances in saliva including 3 each of blood type A or O, and 2 secretors each of A, H or B, H or H substances, including three of blood type A, two of B and one of O. In milk or colostrum, total hexose was normal, range 32 to 96 mg per ml between the 12 women, but 2'-fucosyllactose was for secretors 0.24 to 0.46 mg per ml and in non-secretors none was detected.Results confirm the finding of Kuhnet al. (Chem. Ber., 1955, 88, 1135) that the presence of 2'-fucosyl-lactose was independent of blood type, and support the hypothesis of Watkins and Morgan (Vox San-guinis, 1959, 4, 97) and Watkins (Science, 1966, 152, 172) that the H gene is responsible for the fucosyl transferase necessary for conversion of Lea to Leb substance and production of H substance, later converted to A or B substance, and that its absence in non-secretors allows secretion of Lea substance irrespective of blood type.-M. S.