Organocatalytic functionalization of heteroaromatic N-oxides with C-nucleophiles using in situ generated onium amide bases
Organocatalytic functionalization of heteroaromatic N-oxides with C-nucleophiles using in situ generated onium amide bases
复制标题
DOI：
10.1039/c3ob40782a
复制
发表时间：
2013-07-21
影响因子：
3.2
通讯作者：
Kondo, Yoshinori
中科院分区：
文献类型：
--
作者：
Inamoto, Kiyofumi;Araki, Yuta;Kondo, Yoshinori
在无金属条件下，通过连续加成-消除反应有效地引入了C-亲核化合物，生成了2-取代的氮杂芳烃，产率普遍较高。
Organocatalytic functionalization of heteroaromatic N-oxides was investigated using in situ generated onium amide bases, and C-nucleophiles were efficiently introduced by the sequential addition-elimination reaction under metal-free conditions, affording 2-substituted nitrogen heteroaromatics generally in good to high yields.