Neuroimaging in borderline personality disorder.
Neuroimaging in borderline personality disorder.
复制标题
边缘性人格障碍的神经影像学。
DOI：
10.1016/j.jpsychires.2005.08.011
复制
发表时间：
2006
影响因子：
4.8
通讯作者：
Bremner,JDouglas
中科院分区：
文献类型：
--
作者：
Schmahl,Christian;Bremner,JDouglas
神经影像学已成为研究边缘型人格障碍的神经生物学基础的重要方法之一。结构和功能成像研究揭示了不同脑区功能障碍似乎有助于边缘性症状学。这篇综述介绍了使用不同方法的相关研究：边缘和前额叶区域的体积测量，静息条件下脑代谢的研究，血清素能神经传递的研究，以及使用情绪、压力和感觉刺激的挑战研究。额叶网络的功能障碍被认为介导了大部分（如果不是全部的话）边缘性症状。
Neuroimaging has become one of the most important methods in the investigation of the neurobiological underpinnings of borderline personality disorder. Structural and functional imaging studies have revealed dysfunction in different brain regions which seem to contribute to borderline symptomatology. This review presents relevant studies using different methodologies: volumetry of limbic and prefrontal regions, investigations of brain metabolism under resting conditions, studies of serotonergic neurotransmission, and challenge studies using emotional, stressful, and sensory stimuli. Dysfunction in a frontolimbic network is suggested to mediate much, if not all of the borderline symptomatology.