Oxidative coupling of indoles using thallium(III) trifluoroacetate
Oxidative coupling of indoles using thallium(III) trifluoroacetate
复制标题
DOI：
10.1016/j.tet.2008.05.133
复制
发表时间：
2008-08-11
期刊：
影响因子：
2.1
通讯作者：
White, Allan H.
中科院分区：
文献类型：
--
作者：
Keller, Paul A.;Yepuri, Nageshwar R.;White, Allan H.
人们发现，由三氟乙酸铊介导的多取代富电子吲哚的氧化偶联是一种简便、清洁且高产率的反应。吲哚偶联位点由存在的取代基的性质决定，其中吲哚2位的二聚化是主要结果。另外还发现具有两个具有相似反应性的潜在反应位点的吲哚发生异质偶联。 (C) 2008 Elsevier Ltd. 保留所有权利。
The oxidative coupling of polysubstituted electron-rich indoles mediated by thallium trifluoroacetate was found to be a facile, clean, and high yielding reaction. Indolic coupling sites were determined by the nature of the substituents present, with dimerisation at the indole 2-position being the dominant outcome. Indoles bearing two potential reaction sites with similar reactivity were additionally found to undergo heterocoupling. (C) 2008 Elsevier Ltd. All rights reserved.