In-situ fabrication of well-distributed gold nanocubes on thiol graphene as a third-generation biosensor for ultrasensitive glucose detection
In-situ fabrication of well-distributed gold nanocubes on thiol graphene as a third-generation biosensor for ultrasensitive glucose detection
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DOI：
10.1016/j.electacta.2015.06.123
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发表时间：
2015-09-10
影响因子：
6.6
通讯作者：
Jin, Wanqin
中科院分区：
文献类型：
--
作者：
Chu, Zhenyu;Liu, Yu;Jin, Wanqin
第三代生物传感器由于其先进的酶直接电子转移的工作机理，在近十年来引起了越来越多的关注。在此，一种新的结构的第三代葡萄糖生物传感器的构建通过原位有限电沉积金纳米立方体的硫醇石墨烯膜。由于-SH基团的限制，最初，均匀地形成紧密分布的Au种子层以覆盖石墨烯表面。然后，100 nm的良好定义的Au立方体以上生长具有均匀分布，导致在低的电化学电阻。由于均匀分布和规则纳米结构的协同作用，所制备的传感器在-0.4 V下具有超灵敏的葡萄糖检测响应（221.0 μ A·mM（-1）·cm（-2））。如此低的操作电位也为抗坏血酸和尿酸的存在提供了优异的抗干扰能力。这种新型生物传感器具有突出的灵敏度和选择性，可以进一步发展在更复杂的检测系统的痕量分析。(C)2015爱思唯尔有限公司版权所有。
Because of the advanced work mechanism on enzyme direct electron transfer, third-generation biosensor has aroused the growing attentions in recent decade. Herein, a novel structured 3rd generation glucose biosensor was constructed by the in-situ limited electrodeposition of gold nanocubes on a thiol graphene film. On account of the restriction from -SH group, initially, a tightly distributed Au seed layer was homogeneously formed to cover the graphene surface. Then 100 nm well-defined Au cubes were grown above with a uniform distribution, resulting in the low electrochemical resistance. Due to the synergistic effects of uniform distribution and regular nanostructure, the as-prepared biosensor owned an ultrasensitive response (221.0 mu A.mM(-1).cm(-2)) in glucose detection under -0.4 V. Such a low operation potential also provided an excellent anti-interference ability to the existence of ascorbic acid and uric acid. This new biosensor with outstanding sensitivity and selectivity can be further developed in trace analysis of more complex detection systems. (C) 2015 Elsevier Ltd. All rights reserved.