Hypertension in Reproductive-Aged Women With Polycystic Ovary Syndrome and Association With Obesity
Hypertension in Reproductive-Aged Women With Polycystic Ovary Syndrome and Association With Obesity
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DOI：
10.1093/ajh/hpu251
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发表时间：
2015-07-01
影响因子：
3.2
通讯作者：
Teede, Helena J.
中科院分区：
文献类型：
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作者：
Joham, Anju E.;Boyle, Jacqueline A.;Teede, Helena J.
背景多囊卵巢综合征（PCOS）是一种常见的代谢性疾病，但高血压的患病率尚不清楚。我们的目的是评估高血压患病率和肥胖的影响，在妇女报告PCOS相比，那些没有报告PCOSSithis是一个横断面分析的数据从一个大型的纵向研究，澳大利亚妇女的健康纵向研究（ALSWH）。从全国健康保险数据库中随机挑选了一般社区的妇女。在6个调查时间点进行标准化数据收集。本研究检查了2006年调查4的数据（n = 8，612，年龄：28-33岁）。研究的主要结果指标是自我报告的PCOS和高血压。PCOS的患病率为5.8%（95%可信区间（CI）：5.3%-6.4%）。PCOS妇女的体重指数（BMI）较高。PCOS组高血压患病率为5.5%（95% CI：3.3-7.7），未报告PCOS组为2.0%（95% CI：1.6-2.3），差异有统计学意义（P < 0.001）。高血压与BMI相关（比值比：1.07，95% CI：1.05-1.10，P < 0.001），并有与PCOS相关的趋势（P = 0.09）。在亚组分析中，高血压与报告PCOS的女性BMI无关，但与未报告PCOS的女性BMI相关。CONCLUSIONSSIn this large community-based cohort，我们注意到报告PCOS的年轻女性高血压患病率增加，BMI较高。在未报告PCOS的女性中，BMI与高血压的相关性明显。然而，在PCOS女性中，高血压似乎与BMI无关，类似于PCOS中糖尿病风险的观察结果，表明PCOS中的代谢异常可能与BMI无关。
BACKGROUNDPolycystic ovary syndrome (PCOS) is a common disorder with metabolic complications, yet the prevalence of hypertension is unclear. We aim to assess hypertension prevalence and the impact of obesity in women reporting PCOS compared to those not reporting PCOS.METHODSThis is a cross-sectional analysis of data from a large longitudinal study, the Australian Longitudinal Study on Women's Health (ALSWH). Women from the general community were randomly selected from the national health insurance database. Standardized data collection occurred at 6 survey time points. Data from Survey 4 in 2006 (n = 8,612, age: 28-33 years) were examined for this study. The main outcome measures studied were self-reported PCOS and hypertension.RESULTSReported PCOS prevalence was 5.8% (95% confidence interval (CI): 5.3%-6.4%). Women with PCOS had higher body mass index (BMI). Hypertension prevalence was 5.5% (95% CI: 3.3-7.7) in women reporting PCOS and 2.0% (95% CI: 1.6-2.3) in women not reporting PCOS (P < 0.001). Hypertension was associated with BMI (odds ratio: 1.07, 95% CI: 1.05-1.10, P < 0.001) with a trend towards an association with PCOS (P = 0.09). On subgroup analysis, hypertension was not associated with BMI in women reporting PCOS but was associated in those not reporting PCOS.CONCLUSIONSIn this large community-based cohort, we note increased prevalence of hypertension and higher BMI in young women reporting PCOS. BMI association with hypertension appeared clear in women not reporting PCOS. Yet in women with PCOS, hypertension appeared to not be associated with BMI, akin to observations on diabetes risk in PCOS, suggesting that metabolic abnormalities in PCOS may be independent of BMI.