Bioactive sesquiterpene lactones isolated from the shoots of Arctotis arctotoides
Bioactive sesquiterpene lactones isolated from the shoots of Arctotis arctotoides
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DOI：
10.1016/s0254-6299(15)30339-2
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发表时间：
2003-07-01
影响因子：
3.1
通讯作者：
Afolayan, AJ
中科院分区：
文献类型：
--
作者：
Sultana, N;Afolayan, AJ
Arctotis arctotoides 是一种多年生草本植物，在南非东开普省用于治疗各种疾病。该草药芽的正己烷提取物对枯草芽孢杆菌具有抗菌活性。通过生物测定指导对提取物进行分级分离，分离出两种已知的倍半萜内酯：4β, 15-二氢-3-脱氢-zaluzanin C 和 deHydrachylaenolide。通过广泛使用 1D 和 2D-NMR（1H-1H COSY、HMQC、HMBC）研究阐明了化合物的结构。使用 TLC 板上的生物自显影测定证明了两种化合物的抗菌活性。这两种化合物对革兰氏阳性菌枯草芽孢杆菌表现出显着的抗菌活性。
Arctotis arctotoides is a perennial herb used medicinally for the treatment of various ailments in the Eastern Cape, South Africa. The n-hexane extract from the shoots of the herb showed antimicrobial activity against Bacillus subtilis. Bioassay guided fractionation of the extract has led to the isolation of two known sesquiterpene lactones, 4beta, 15-dihydro-3-dehydro-zaluzanin C and dehydrobrachylaenolide. The structures of the compounds were elucidated by extensive use of 1D and 2D-NMR (1H-1H COSY, HMQC, HMBC) studies. The antibacterial activity of the two compounds was demonstrated using bioautographic assay on TLC plates. The two compounds showed significant antibacterial activity against Bacillus subtilis, a Gram-positive bacterium.