Roles of Adipokines in Digestive Diseases: Markers of Inflammation, Metabolic Alteration and Disease Progression.
Roles of Adipokines in Digestive Diseases: Markers of Inflammation, Metabolic Alteration and Disease Progression.
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脂肪因子在消化系统疾病中的作用：炎症、代谢改变和疾病进展的标志物。
DOI：
10.3390/ijms21218308
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发表时间：
2020-11-05
影响因子：
5.6
通讯作者：
Yang SS
中科院分区：
文献类型：
--
作者：
Chang ML;Yang Z;Yang SS
脂肪组织是一种高度动态的内分泌组织，并通过脂肪因子构成器官间串扰网络的中心节点，其引起多效性效应，包括调节血管生成、代谢和炎症。具体地说，消化道癌症在解剖学上靠近脂肪组织生长。在与癌细胞相互作用期间，脂肪细胞被重编程为癌症相关脂肪细胞并分泌脂肪因子以影响肿瘤细胞。此外，肝脏是中央代谢枢纽。脂肪组织和肝脏通过脂肪因子协同调节全身能量平衡。肥胖症是由于增生和肥大引起的脂肪组织过度积累，目前被认为是全球流行病，并且与以脂肪因子调节改变为特征的低度全身性炎症有关。肥胖相关的消化系统疾病，包括胃食管反流病、巴雷特食管、食管癌、结肠息肉和癌症、非酒精性脂肪肝、病毒性肝炎相关疾病、胆石症、胆囊癌、胆管癌、胰腺癌和糖尿病，可能导致脂肪因子谱的特定改变。这些模式和相关的基础可能有助于识别相关消化系统疾病的预后生物标志物和治疗方法。本文综述了脂肪因子谱改变与消化系统疾病（包括肝脏、胰腺、胃肠道和胆道疾病）相关的重要发现，并展望了其临床意义和机制探索。
Adipose tissue is a highly dynamic endocrine tissue and constitutes a central node in the interorgan crosstalk network through adipokines, which cause pleiotropic effects, including the modulation of angiogenesis, metabolism, and inflammation. Specifically, digestive cancers grow anatomically near adipose tissue. During their interaction with cancer cells, adipocytes are reprogrammed into cancer-associated adipocytes and secrete adipokines to affect tumor cells. Moreover, the liver is the central metabolic hub. Adipose tissue and the liver cooperatively regulate whole-body energy homeostasis via adipokines. Obesity, the excessive accumulation of adipose tissue due to hyperplasia and hypertrophy, is currently considered a global epidemic and is related to low-grade systemic inflammation characterized by altered adipokine regulation. Obesity-related digestive diseases, including gastroesophageal reflux disease, Barrett’s esophagus, esophageal cancer, colon polyps and cancer, non-alcoholic fatty liver disease, viral hepatitis-related diseases, cholelithiasis, gallbladder cancer, cholangiocarcinoma, pancreatic cancer, and diabetes, might cause specific alterations in adipokine profiles. These patterns and associated bases potentially contribute to the identification of prognostic biomarkers and therapeutic approaches for the associated digestive diseases. This review highlights important findings about altered adipokine profiles relevant to digestive diseases, including hepatic, pancreatic, gastrointestinal, and biliary tract diseases, with a perspective on clinical implications and mechanistic explorations.
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