Screening of bioactive metabolites for pancreatic regeneration chemotherapy
Screening of bioactive metabolites for pancreatic regeneration chemotherapy
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DOI：
10.1016/j.biopha.2004.10.003
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发表时间：
2004-12-01
影响因子：
7.5
通讯作者：
Umezawa, K
中科院分区：
文献类型：
--
作者：
Takatsuna, H;Umezawa, K
植物和微生物是生物活性代谢物的宝库，包括有用的化学配体。诱导β细胞分化的化学配体可能成为治疗1型和2型糖尿病的新药物。我们从小叶Ervatamia microphylla叶中分离出一种诱导大鼠胰腺腺癌细胞产生胰岛素的药物——茶碱。(C) 2004 Elsevier SAS。版权所有。
Plants and microorganisms are the treasury of bioactive metabolites including useful chemical ligands. Chemical ligands that induce beta-cell differentiation may be useful as new therapeutic agents for both type-1 and type-2 diabetes mellitus. We isolated conophylline from the leaves of Ervatamia microphylla as an agent that induce insulin production in rat pancreatic acinar carcinoma cells. (C) 2004 Elsevier SAS. All rights reserved.