The neutrophil to lymphocyte and platelet to lymphocyte ratios as biomarkers for lung cancer development
The neutrophil to lymphocyte and platelet to lymphocyte ratios as biomarkers for lung cancer development
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DOI：
10.1016/j.lungcan.2016.04.010
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发表时间：
2016-07-01
期刊：
影响因子：
5.3
通讯作者：
Zulueta, Javier J.
中科院分区：
文献类型：
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作者：
Sanchez-Salcedo, Pablo;de-Torres, Juan P.;Zulueta, Javier J.
目的：在癌症诊断时升高的嗜中性粒细胞与淋巴细胞比率（NLR）和血小板与淋巴细胞比率（PLR）与各种癌症的不良预后相关。在癌症诊断确定之前，没有关于其自然进展的数据。我们的目的是评估这些比例的年度变化是否可以早期指标肺癌development.Materials和方法：参加者招募到潘普洛纳国际早期肺癌行动计划（P-IELCAP，n =3061）之间的2001年和2015年被认为是。全血细胞计数（CBC）在入组和诊断时间之间每年登记一次。线性回归用于计算NLR和PLR在>= 3CBC的参与者中的平均年变化。相对于基线值表示变化。计算不同NLR和PLR年阈值（= 0%，>= 1%，>= 2%，>= 4%）的肺癌发病密度和肺癌风险（考克斯回归分析）。结果：在中位随访80个月和中位数4（IQR 3-6）CBC后，患肺癌的受试者（n = 32）比匹配的对照组（n = 103）显示出更大的NLR和PLR年变化（分别为每年2.56% vs. 0.27% [p = 0.25];每年3.75% vs. 0.33% [p = 0.053]）。随着年NLR和PLR阈值的升高，每100人年的肺癌发病率密度增加。在多变量分析中（校正肺气肿和基线肺功能），NLR和PLR不是显著的肺癌预测因子。然而，在肺气肿患者中，PLR每增加一个相对单位，肺癌风险增加5%（p = 0.03）。PLR增加和肺气肿之间存在显著的超加性风险效应。结论：在肺癌筛查环境中，评估年PLR变化有助于预测肺癌的发展。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Objectives: Elevated neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) at time of cancer diagnosis have been associated to poor prognosis in various cancers. There is no data on their natural progression before the cancer diagnosis has been established. We aim to evaluate whether or not the annual changes in these ratios could be early indicators of lung cancer development.Materials and methods: Participants recruited into the Pamplona International Early Lung Cancer Action Program (P-IELCAP, n =3061) between 2001 and 2015 were considered. Complete blood counts (CBC) were registered at annual intervals between enrolment and time of diagnosis. Linear regression was used to calculate the mean annual change in NLR and PLR in participants with >= 3CBCs. Changes were expressed relative to baseline values. Lung cancer incidence density and lung cancer risk (Cox regression analysis) were calculated for different NLR and PLR annual thresholds (= 0%, >= 1%, >= 2%, >= 4%). Results were compared to a matched group of participants who did not develop lung cancer.Results: After a median follow-up of 80 months and a median of 4 (IQR 3-6) CBCs, subjects who developed lung cancer (n = 32) showed greater NLR and PLR annual changes than matched controls (n = 103) (2.56% vs. 0.27% [p = 0.25] per year; and 3.75% vs. 0.33% [p = 0.053] per year, respectively). Lung cancer incidence density per 100 person-years increased with higher annual NLR and PLR thresholds. On multivariable analysis (adjusting for emphysema and baseline lung-function), NLR and PLR were not significant lung cancer predictors. However, among individuals with emphysema, for each relative unit increase in PLR, lung cancer risk increased 5% (p = 0.03). There was a significant supra-additive risk effect between PLR increase and emphysema. Annual NLR change was not a significant lung cancer predictor.Conclusion: In a lung cancer screening setting, the assessment of annual PLR change could help predict lung cancer development. (C) 2016 Elsevier Ireland Ltd. All rights reserved.