Safety and usefulness of minor salivary gland biopsy: retrospective analysis of 502 procedures performed at a single center
Safety and usefulness of minor salivary gland biopsy: retrospective analysis of 502 procedures performed at a single center
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DOI：
10.1002/art.23579
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发表时间：
2008-05-15
期刊：
影响因子：
--
通讯作者：
Montecucco, Carlomaurizio
中科院分区：
文献类型：
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作者：
Caporali, Roberto;Bonacci, Eleonora;Montecucco, Carlomaurizio
Objective.目的分析小涎腺活检术（MSGB）诊断干燥综合征（SS）和淀粉样变性的安全性和有效性。我们对452例疑似SS患者和50例疑似淀粉样变性且脐周脂肪抽吸分析阴性的患者进行了回顾性分析，这些患者在一家中心接受了MSGB。SS的诊断评价包括Schirmer's。试验、未刺激的全唾液流、抗核抗体和抗SSA/SSB检测、红细胞沉降率、C反应蛋白、IgM类风湿因子和丙型肝炎病毒血清学。对于所有活检样本，计算多层切片上的累积病灶评分。SS的诊断依据为美国-欧洲共识组（AECG）标准。使用刚果红染色和偏振光显微镜进行淀粉样变性的组织学评价。术后即刻、术后7天、术后14天、术后6个月分别对不良事件进行问卷调查。64例患者（12.7%）报告了一过性不良事件：40例持续感觉异常，
Objective. To analyze the safety of our biopsy technique and the effectiveness of minor salivary gland biopsy (MSGB) for the diagnosis of Sjogren's syndrome (SS) and amyloidosis.Methods. We conducted a retrospective analysis of 452 patients with suspected SS and 50 with suspected amyloidosis and negative periumbilical fat aspiration analysis who underwent MSGB at a single center. Diagnostic evaluation for SS included Schirmer's. test, unstimulated whole salivary flow, detection of antinuclear antibodies and anti-SSA/SSB, erythrocyte sedimentation rate, C-reactive protein, IgM rheumatoid factor, and serology for hepatitis C virus. For all biopsy samples, a cumulative focus score on multilevel sections was calculated. SS Was diagnosed according to American-European Consensus Group (AECG) criteria. Histologic evaluation for amyloidosis was performed using Congo red staining and polarized-light, microscopy. Adverse events were recorded on a questionnaire immediately after the procedure and 7 days, 14 days, and 6 months thereafter.Results. Sixty-four patients (12.7%) reported transient adverse events: 40 paresthesias lasting,