A vision on the future of articular cartilage repair.
A vision on the future of articular cartilage repair.
复制标题
对关节软骨修复未来的愿景。
DOI：
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发表时间：
2014
影响因子：
3.1
通讯作者：
P. Roughley
中科院分区：
文献类型：
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作者：
M. Cucchiarini;H. Madry;F. Guilak;D. Saris;M. Stoddart;M. Wong;P. Roughley
2013年9月5日至7日，达沃斯，“科学与临床”研讨会上，由AO基金会（瑞士达沃斯）主办的“软骨修复中的细胞治疗”研讨会聚集了来自医学、科学、工业和监管组织的领导人，讨论了关节软骨修复中细胞治疗的愿景，以及可以采取的措施，以缩小愿景与当前实践之间的差距。以细胞为基础的治疗已经在临床应用于增强软骨损伤的修复，如微骨折和关节软骨细胞植入。然而，尽管从临床角度来看，长期随访是好的，再生医学/矫形外科领域一些最严格的随机对照试验也显示出有益的效果，但迄今为止，这些选择都没有被证明能成功地恢复患者原有的关节软骨结构和功能。随着最近在细胞生物学（软骨细胞、干细胞的新来源）、分子生物学（生长因子、基因）、生物材料、生物力学和转化科学的实验研究取得显著进展，具有广泛专业知识的科学家和临床医生之间的共同努力可能会使软骨修复的细胞疗法得到改进。本立场文件描述了该领域的最新技术，以帮助定义适应临床情况的程序，以便在患者中进行即将到来的翻译。
An AO Foundation (Davos, Switzerland) sponsored workshop "Cell Therapy in Cartilage Repair" from the Symposium "Where Science meets Clinics" (September 5-7, 2013, Davos) gathered leaders from medicine, science, industry, and regulatory organisations to debate the vision of cell therapy in articular cartilage repair and the measures that could be taken to narrow the gap between vision and current practice. Cell-based therapy is already in clinical use to enhance the repair of cartilage lesions, with procedures such as microfracture and articular chondrocyte implantation. However, even though long term follow up is good from a clinical perspective and some of the most rigorous randomised controlled trials in the regenerative medicine/orthopaedics field show beneficial effect, none of these options have proved successful in restoring the original articular cartilage structure and functionality in patients so far. With the remarkable recent advances in experimental research in cell biology (new sources for chondrocytes, stem cells), molecular biology (growth factors, genes), biomaterials, biomechanics, and translational science, a combined effort between scientists and clinicians with broad expertise may allow development of an improved cell therapy for cartilage repair. This position paper describes the current state of the art in the field to help define a procedure adapted to the clinical situation for upcoming translation in the patient.