A Pilot Study of Digital Indocyanine Green Videoangiography for Recurrent Occult Choroidal Neovascularization in Age-Related Macular Degeneration
A Pilot Study of Digital Indocyanine Green Videoangiography for Recurrent Occult Choroidal Neovascularization in Age-Related Macular Degeneration
复制标题
数字吲哚菁绿视频血管造影治疗年龄相关性黄斑变性复发性隐匿性脉络膜新生血管的初步研究
DOI：
10.1001/archopht.1994.01090160049021
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发表时间：
1994
影响因子：
--
通讯作者：
D. Orlock
中科院分区：
文献类型：
--
作者：
J. Sorenson;L. Yannuzzi;J. Slakter;D. Guyer;A. Ho;D. Orlock
目的：数字化吲哚菁绿色视频血管造影（ICG-V）用于研究临床和荧光素血管造影结果提示不明确或复发性隐匿性CNV（RO-CNV）患者的复发性脉络膜新生血管（CNV）。ICG-V引导的激光caphotocoagulation作为一种替代形式的治疗也进行了研究，当一个良好的划定区域的CNV成像与此技术。研究方法：对66例渗出性年龄相关性黄斑变性和复发性CNV的症状和临床表现进行了连续研究，其中荧光素血管造影未显示经典或明确的新生血管形成。如果ICG-V成像的复发CNV区域轮廓清晰，则根据常规指南选择患者进行激光治疗。结果：吲哚菁绿色血管造影显示晚期染色与66例RO-CNV患者中64例（97%）复发CNV一致。66例患者中有29例（44%）符合激光治疗的条件，这29例患者中有18例（62%）获得了成功的解剖学和视力结果，定义为渗出性表现消退以及视力改善或稳定（Snellen视力表上±1线）。结论：这项初步研究表明，ICG-V在对继发于年龄相关性黄斑变性的CNV进行激光光凝后的RO-CNV患者进行成像时具有价值。在ICG-V引导下，RO-CNV的激光治疗在解剖学和功能上都可能成功，这在许多其他无法治疗的病例中是有希望的。需要进一步的研究来验证这些初步发现。
Purpose: Digital indocyanine green videoangiography (ICG-V) was used to study recurrent choroidal neovascularization (CNV) in patients with the clinical and fluorescein angiographic findings indicative of ill-defined, or recurrent occult, CNV (RO-CNV). The use of ICG-V-guided laser caphotocoagulation as an alternative form of treatment was also investigated when a well-delineated area of CNV was imaged with this technique. Methods: A consecutive series of 66 patients were studied who presented with exudative age-related macular degeneration and symptoms and clinical manifestations of recurrent CNV in which fluorescein angiography did not reveal classic, or well-defined, neovascularization. Patients were selected for laser treatment based on conventional guidelines if ICG-V imaged a well-delineated area of recurrent CNV. Results: Indocyanine green videoangiography showed late staining that was consistent with recurrent CNV in 64 (97%) of these 66 patients with RO-CNV. Twenty-nine (44%) of the 66 were eligible for laser treatment, and 18 (62%) of these 29 patients experienced successful anatomic and visual results, which were defined as resolution of the exudative manifestations and improvement or stabilization (±1 line on a Snellen chart) of vision. Conclusions: This pilot study suggests that ICG-V is of value in imaging patients with RO-CNV after laser photocoagulation for CNV secondary to age-related macular degeneration. Laser treatment of RO-CNV with ICG-V guidance may be successful both anatomically and functionally in a promising number of these otherwise untreatable cases. Further studies are necessary to validate these preliminary findings.
脉络膜新生血管的吲哚菁绿视频血管造影。
影响因子：
13.7
作者：
Destro,M;Puliafito,CA
通讯作者：
Puliafito,CA
影响因子：
--
作者：
T. Meredith;P. Sternberg;J. M. Brown;R. Murphy;S. Fine;A. Schachat;M. Elman;N. Bressler;J. Haller;P. Orr;J. Starr;K. MacMillan;L. Singerman;T. Rice;M. Novak;S. Smith-Brewer;D. Preseren;G. Fish;B. Jost
通讯作者：
T. Meredith;P. Sternberg;J. M. Brown;R. Murphy;S. Fine;A. Schachat;M. Elman;N. Bressler;J. Haller;P. Orr;J. Starr;K. MacMillan;L. Singerman;T. Rice;M. Novak;S. Smith-Brewer;D. Preseren;G. Fish;B. Jost