Synthesis and pharmacological profile of serofendic acids A and B
Synthesis and pharmacological profile of serofendic acids A and B
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DOI：
10.1016/j.bmc.2007.07.037
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发表时间：
2007-11-15
影响因子：
3.5
通讯作者：
Sugimoto, Hachiro
中科院分区：
文献类型：
--
作者：
Terauchi, Taro;Asai, Naoki;Sugimoto, Hachiro
我们展示了丝罗芬酸 A 和 B（SA-A 和 SA-B）的高效合成，这是从胎牛血清中分离出来的新型神经保护物质。生物学和药理学评价表明，SA-A和SA-B对谷氨酸引起的神经毒性具有有效的保护作用，但不与谷氨酸受体直接相互作用。药代动力学研究表明它们在大鼠中具有良好的口服生物利用度。结果表明，SA-A 和 SA-B 是治疗各种神经系统疾病候选药物的潜在先导化合物。 (C) 2007 Elsevier Ltd. 保留所有权利。
We present efficient syntheses of serofendic acids A and B (SA-A and SA-B), novel neuroprotective substances isolated from fetal calf serum. Biological and pharmacological evaluation showed that SA-A and SA-B have potent protective action aaainst glutarnate-induced neurotoxicity, but do not interact directly with glutamate receptors. A pharmacokinetic study showed that they have good oral bioavailability in rats. The results indicate that SA-A and SA-B are potential lead compounds for candidate drugs to treat various neuroloaical disorders. (C) 2007 Elsevier Ltd. All rights reserved.