Normative fetal brain growth by quantitative in vivo magnetic resonance imaging
Normative fetal brain growth by quantitative in vivo magnetic resonance imaging
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DOI：
10.1016/j.ajog.2011.10.002
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发表时间：
2012-02-01
影响因子：
9.8
通讯作者：
Limperopoulos, Catherine
中科院分区：
文献类型：
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作者：
Clouchoux, Cedric;Guizard, Nicolas;Limperopoulos, Catherine
目的：这项研究的目的是在第二和第三个三个月的怀孕期间，健康胎儿的总体积和区域的脑生长的特点，使用自动化的方法。研究设计：我们开发和验证了一种自动化的方法来量化全球和区域的体内脑体积使用胎儿磁共振成像。然后，我们计算了64个健康胎儿（胎龄25.4-36.6周）的队列中每个脑结构的生长百分比。结果：小脑表现出最大的成熟率，在25.4和36.6周之间体积增加了4倍（384%），每周的相对生长率为12.87%。在相同胎龄期间，总脑和脑体积增加了230%，脑干体积增加了134%。相反，侧脑室容积下降了4.18%，每周。结论：正常的胎儿脑生长轨迹的可用性和持续验证将提供重要的工具，为早期检测受损的胎儿脑生长后，管理高危妊娠。
OBJECTIVE: The objective of the study was to characterize total and regional volumetric brain growth in healthy fetuses during the second and third trimesters of pregnancy, using an automated method.STUDY DESIGN: We developed and validated an automated method to quantify global and regional in vivo brain volumes using fetal magnetic resonance imaging. We then computed the percentage of growth for each brain structure in a cohort of 64 healthy fetuses (25.4-36.6 weeks' gestational age).RESULTS: The cerebellum demonstrated the greatest maturation rate, with a 4-fold increase (384%) in volume between 25.4 and 36.6 weeks, and a relative growth rate of 12.87% per week. Both total brain and cerebral volumes increased by 230% and brain stem volume by 134% over the same gestational age period. Conversely, lateral ventricular volume decreased by 4.18% per week.CONCLUSION: The availability and ongoing validation of normative fetal brain growth trajectories will provide important tools for early detection of impaired fetal brain growth upon which to manage high-risk pregnancies.