Impact of granulocyte colony-stimulating factor use during induction for acute myelogenous leukemia in children: A report from the children's cancer group
Impact of granulocyte colony-stimulating factor use during induction for acute myelogenous leukemia in children: A report from the children's cancer group
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DOI：
10.1097/00043426-200211000-00006
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发表时间：
2002-11-01
影响因子：
1.2
通讯作者：
Woods, WG
中科院分区：
文献类型：
--
作者：
Alonzo, TA;Kobrinsky, NL;Woods, WG
Purpose: To determine whether granulocyte colony-stimulating factor (G-CSF) administered during acute myelogenous leukemia (AML) induction affects hematopoietic and nonhematopoietic toxicity, length and outcome of induction therapy, event-free survival, overall survival, and prognostic significance of the day 7 bone marrow.Patients and Methods: In Children's Cancer Group study 2891, patients were given intensively timed induction with G-CSF (n = 254) after accrual for the regimen without G-CSF (n = 258) was met.Results: Time to neutropenic recovery after induction courses I and 2 was significantly shorter for patients who received G-CSF. Times to platelet recovery were similar regardless of G-CSF use. Effects on incidence of grades 3 and 4 toxicities, infections, or fatal infections were not observed. Use of G-CSF reduced the median length of induction by 9 days and hospital stay by 6 days. Induction remission rates, overall survival, and event-free survival were similar with and without G-CSF. Day 7 bone marrow was prognostic of better long-term outcome. Patients with hypercellular day 7 marrow who received G-CSF had a higher remission rate and event-free survival than patients who did not receive G-CSFConclusions: The incidence of severe toxic event and infection induction remission rate, overall survival, and event-free survival were comparable regardless of G-CSF use. Use of G-CSF decreased neutropenia duration, hospital stay, and length of induction. Patients with hypercellular day 7 bone marrow who received G-CSF had an induction remission rate and event-free survival superior to those of patients who did not receive G-CSF.
