Neuroprotective effects of hydrogen sulfide and the underlying signaling pathways
Neuroprotective effects of hydrogen sulfide and the underlying signaling pathways
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硫化氢的神经保护作用及其潜在信号通路
DOI：
10.1515/revneuro-2014-0051
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发表时间：
2015-04-01
影响因子：
4.1
通讯作者：
Tang, Xiao-Qing
中科院分区：
文献类型：
--
作者：
Chen, Wen-Lin;Niu, Ying-Ying;Tang, Xiao-Qing
硫化氢（H2S）是一种内源性产生的气体，代表了一种新的第三种气体信号分子，神经递质和细胞保护剂。胱硫醚β-合酶（CBS）、胱硫醚γ-裂解酶（CSE）、3-巯基丙酮酸硫转移酶与半胱氨酸氨基转移酶（3-MST/CAT）和3-巯基丙酮酸硫转移酶与D-氨基酸氧化酶（3-MST/DAO）途径参与内源性H2S的产生，尽管这些酶普遍存在或分布受限。CBS、3-MST/CAT和3-MST/DAO主要分布于脑内，而CSE则广泛分布于其他器官。H_2S代谢中还存在摄取或再循环和清除机制，以维持其生理功能的持久性。近年来，研究硫化氢在中枢神经系统和心血管系统中的作用一直是研究的热点。迄今为止，H2S的影响至少部分地在阿尔茨海默病、帕金森病、脑缺血、重度抑郁症和热性惊厥的多种动物模型或神经元细胞系中得到验证，尽管后续研究仍然非常需要。本文概述了目前对H2S的认识，重点是其神经保护作用和相应的信号通路，以及与临床潜在治疗策略的联系。
Hydrogen sulfide (H2S) is an endogenously produced gas that represents a novel third gaseous signaling molecule, neurotransmitter and cytoprotectant. Cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), 3-mercaptopyruvate sulfur transferase with cysteine aminotransferase (3-MST/CAT) and 3-mercaptopyruvate sulfur transferase with D-amino acid oxidase (3-MST/DAO) pathways are involved in the generation of endogenous H2S despite the ubiquitous or restricted distribution of those enzymes. CBS, 3-MST/CAT and 3-MST/DAO can be found in the brain, while CSE is widely located in other organs. There also exist up-taking or recycling and scavenging mechanisms in H2S metabolism to maintain its persistence for physiological function. In recent years, investigating the role that H2S plays in the central nervous system and cardiovascular system has always been a hotspot. To date, effects of H2S are at least partially verified in multiple animal models or neuron cell lines of Alzheimer's disease, Parkinson's disease, cerebral ischemia, major depression disorders and febrile seizure, although subsequent studies are still badly needed. This article presents an overview of current knowledge of H2S focusing on its neuroprotective effects and corresponding signaling pathways, together with connections to potential therapeutic strategies in the clinic.