Strategies to Improve Regeneration of the Soft Palate Muscles After Cleft Palate Repair
Strategies to Improve Regeneration of the Soft Palate Muscles After Cleft Palate Repair
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DOI：
10.1089/ten.teb.2012.0049
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发表时间：
2012-12-01
影响因子：
6.4
通讯作者：
Von den Hoff, Johannes W.
中科院分区：
文献类型：
--
作者：
Monroy, Paola L. Carvajal;Grefte, Sander;Von den Hoff, Johannes W.
患有软腭裂的儿童会出现言语、吞咽和吸吮困难。这些患者无法将鼻腔与口腔分开，导致说话时空气流失。尽管手术修复通过连接软腭裂肌来改善软腭功能，但通常无法实现最佳功能。手术后软腭肌肉的再生受到阻碍，因为（1）其内在再生能力低，（2）与裂开相关的肌肉特性，以及（3）纤维化的发展。基于组织工程的辅助策略可以通过解决这些具体问题来改善手术后的结果。因此，本文将讨论非腭裂和腭裂的肌发生、软腭肌肉的特征以及肌肉再生的过程。最后，提出了基于组织工程的新治疗策略，以改善手术修复后的软腭功能。
Children with a cleft in the soft palate have difficulties with speech, swallowing, and sucking. These patients are unable to separate the nasal from the oral cavity leading to air loss during speech. Although surgical repair ameliorates soft palate function by joining the clefted muscles of the soft palate, optimal function is often not achieved. The regeneration of muscles in the soft palate after surgery is hampered because of (1) their low intrinsic regenerative capacity, (2) the muscle properties related to clefting, and (3) the development of fibrosis. Adjuvant strategies based on tissue engineering may improve the outcome after surgery by approaching these specific issues. Therefore, this review will discuss myogenesis in the noncleft and cleft palate, the characteristics of soft palate muscles, and the process of muscle regeneration. Finally, novel therapeutic strategies based on tissue engineering to improve soft palate function after surgical repair are presented.