Fourth generation e-cigarette vaping induces transient lung inflammation and gas exchange disturbances: results from two randomized clinical trials
Fourth generation e-cigarette vaping induces transient lung inflammation and gas exchange disturbances: results from two randomized clinical trials
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DOI：
10.1152/ajplung.00492.2018
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发表时间：
2019-05-01
影响因子：
4.9
通讯作者：
Debbass, Nadia
中科院分区：
文献类型：
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作者：
Chaumont, Martin;van de Borne, Philippe;Debbass, Nadia
当被电子香烟加热时，丙二醇和甘油会产生一种携带尼古丁的气雾剂。这种吸湿性/高渗性气溶胶可存款在肺深处。这些沉积物是否引发局部炎症并干扰肺部气体交换尚不清楚。本研究的目的是评估高瓦数电子烟vaping与或不尼古丁对肺部炎症生物标志物，经皮气体张力和肺功能测试的急性影响在年轻和健康的吸烟者。在怀疑患有冠状动脉疾病的重度吸烟者中，还评估了无尼古丁的电子烟对动脉血气紧张度的急性影响。使用单盲受试者内研究设计，25名年轻的烟草吸烟者以随机顺序接受了三个实验阶段：假电子烟和60 W的尼古丁和尼古丁。在一项开放标签、随机平行研究中，20名重度吸烟者也暴露于假电子烟（n = 10）或不含尼古丁的电子烟（n = 10）。在年轻的吸烟者中，与假吸烟相比：1）在没有尼古丁的情况下吸烟后，血清俱乐部细胞蛋白-16增加（平均值+/- SE，-0.5 +/- 0.2 vs. + 1.1 +/- 0.3 μ g/l，P = 0.013）和尼古丁蒸汽烟（+1.2 ± 0.3 μ g/l，P = 0.009）; 2）在没有尼古丁的情况下吸烟后，经皮氧分压下降60分钟（最低点，-0.3 +/- 1 vs. -15.3 +/- 2.3 mmHg，P = 0.001）和尼古丁蒸汽烟后80分钟（最低点，-19.6 +/- 2.8 mmHg，P = 0.001）。与假电子烟相比，不含尼古丁的电子烟降低了重度吸烟患者的动脉氧分压5分钟（+ 5.4 +/- 3.3 vs- 5.4 +/- 1.9 mmHg，P = 0.012）。在有或没有尼古丁的情况下，高瓦数的丙二醇/甘油气雾剂的急性汽化在年轻吸烟者中诱导气道上皮损伤和经皮氧张力的持续降低。剧烈的电子烟条件还会暂时损害重度吸烟者的动脉氧分压。
When heated by an electronic cigarette, propylene glycol and glycerol produce a nicotine-carryingaerosol. This hygroscopic/hyperosmolar aerosol can deposit deep within the lung. Whether these deposits trigger local inflammation and disturb pulmonary gas exchanges is not known. The aim of this study was to assess the acute effects of high-wattage electronic cigarette vaping with or without nicotine on lung inflammation biomarkers, transcutaneous gas tensions, and pulmonary function tests in young and healthy tobacco smokers. Acute effects of vaping without nicotine on arterial blood gas tensions were also assessed in heavy smokers suspected of coronary artery disease. Using a single-blind withinsubjects study design, 25 young tobacco smokers underwent three experimental sessions in random order: sham-vaping and vaping with and without nicotine at 60 W. Twenty heavy smokers were also exposed to sham-vaping (n = 10) or vaping without nicotine (n = 10) in an open-label, randomized parallel study. In the young tobacco smokers, compared with sham-vaping: 1) serum club cell protein-16 increased after vaping without nicotine (mean +/- SE, -0.5 +/- 0.2 vs. + 1.1 +/- 0.3 mu g/l, P = 0.013) and vaping with nicotine (+1.2 +- 0.3 mu g/l, P = 0.009); 2) transcutaneous oxygen tension decreased for 60 min after vaping without nicotine (nadir, -0.3 +/- 1 vs. -15.3 +/- 2.3 mmHg, P = 0.001) and for 80-min after vaping with nicotine (nadir, -19.6 +/- 2.8 mmHg, P = 0.001). Compared with sham vaping, vaping without nicotine decreased arterial oxygen tension for 5 min in heavy-smoking patients (+ 5.4 +/- 3.3 vs. - 5.4 +/- 1.9 mmHg, P = 0.012). Acute vaping of propylene glycol/glycerol aerosol at high wattage with or without nicotine induces airway epithelial injury and sustained decrement in transcutaneous oxygen tension in young to-bacco smokers. Intense vaping conditions also transiently impair arterial oxygen tension in heavy smokers.