Osteoclastogenic Activity during Mandibular Distraction Osteogenesis
Osteoclastogenic Activity during Mandibular Distraction Osteogenesis
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DOI：
10.1177/154405910508401108
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发表时间：
2005-11
影响因子：
7.6
通讯作者：
L. C. Wang;Ichiro Takahashi;Y. Sasano;J. Sugawara;H. Mitani
中科院分区：
文献类型：
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作者：
L. C. Wang;Ichiro Takahashi;Y. Sasano;J. Sugawara;H. Mitani
下颌牵引成骨是一种成熟的临床治疗方式，可与正畸治疗相结合，用于治疗颅面畸形和牙弓差异。然而，在我们之前的研究中，正畸牙齿移动到牵张间隙会导致严重的牙根吸收。本研究旨在阐明牵引间隙中细胞的破骨细胞活性。我们假设在巩固期，成骨细胞和基质细胞中破骨细胞和破骨细胞支持分子的基因表达会在牵引部位增加。设计了兔子下颌骨牵张成骨动物模型实验，并进行了原位杂交分析。由于成骨细胞中破骨细胞因子的基因表达增加，早期巩固期牵引间隙中的破骨细胞数量比正常对照更大。结论是，在早期巩固期，牵引部位的破骨细胞和破骨细胞活性受到刺激。
Mandibular distraction osteogenesis is a well-developed clinical modality for the treatment of craniofacial deformities and dental arch discrepancies, in combination with orthodontic treatment. However, in our previous study, orthodontic tooth movement into the distraction gap caused severe root resorption. The present study aimed to clarify the osteoclastogenic activity of cells in the distraction gap. We hypothesized that the gene expression of osteoclastogenic- and osteoclast-supporting molecules in osteoblasts and stromal cells would increase at distraction sites during the consolidation period. An animal model experiment involving rabbits was designed for mandibular distraction osteogenesis and subjected to in situ hybridization analysis. The number of osteoclasts was larger in the distraction gap during the early consolidation period than in normal controls, due to an increase of gene expression for osteoclastogenic cytokines in osteoblasts. It was concluded that osteoclastogenic and osteoclastic activities are stimulated at distraction sites during the early consolidation period.