Desmethylimipramine and imipramine on left ventricular function and the ECG: a randomized crossover design.
Desmethylimipramine and imipramine on left ventricular function and the ECG: a randomized crossover design.
复制标题
去甲基丙咪嗪和丙咪嗪对左心室功能和心电图的影响：随机交叉设计。
DOI：
10.1016/0167-5273(83)90009-8
复制
发表时间：
1983
影响因子：
3.5
通讯作者：
Davis,JC
中科院分区：
文献类型：
--
作者：
Giardina,EG;BiggerJr,JT;Glassman,AH;Perel,JM;Saroff,AL;Roose,SP;Siris,SG;Davis,JC
16名重度抑郁症患者参加了一项双盲、随机、交叉研究，以比较去甲基米帕明和丙咪嗪对左心功能和心电图的影响。在停药一周后，患者分别接受3周的去甲基米帕明和丙咪嗪治疗。在每个治疗期间记录收缩时间间隔、超声心动图和高保真心电图。去甲基米帕明和丙咪嗪在(1)收缩时间间期、(2)环向缩短分数或平均速度、(3)心电图方面无差异。停药时间对PEPc(P<；0.05)、PEP-LVET比值(P<；0.05)、RR(P<；0.05)、PR(P<；0.05)、QRS(P<；0.05)、QTc(P<；0.05)有差异，但对LVETc、短轴缩短率和平均周向缩短速度无差异。去甲基米帕明和丙咪嗪等延长脑室内传导的药物可能会延长PEP和PEP LVET。因此，心脏收缩时间间隔在评估心肌功能方面有局限性，而超声心动图更可靠地评估接受三环类抗抑郁药物治疗的患者的心肌功能。
Sixteen severely depressed patients participated in a double-blind randomized, crossover study to compare the effects of desmethylimipramine and imipramine on left ventricular function and the electrocardiogram. Following a drug-free week, patients had 3 weeks of therapy each with desmethylimipramine and imipramine. During each treatment period systolic time intervals, echocardiograms and high-fidelity electrocardiograms were recorded. There was no difference between desmethylimipramine and imipramine on (1) systolic time intervals,(2) shortening fraction or mean velocity of circumferential shortening, or (3) the electrocardiogram. There was a difference between the drug-free period and desmethylimipramine or imipramine on the PEPc (P< 0.05) and the PEP LVET ratio (P< 0.05); on the RR (P< 0.05), PR (P< 0.05), QRS (P< 0.05), and QTc (P< 0.05) intervals; but no difference on the LVETc or shortening fraction or the mean velocity of circumferential shortening. Drugs such as desmethylimipramine and imipramine which prolong intraventricular conduction can probably be expected to prolong the PEP and PEP LVET. For this reason systolic time intervals have limitations in assessing myocardial function and the echocardiogram more reliably estimates myocardial performance in patients receiving tricyclic antidepressants.