Brief depression screening with the PHQ-2 associated with prognosis following percutaneous coronary intervention with paclitaxel-eluting stenting.
Brief depression screening with the PHQ-2 associated with prognosis following percutaneous coronary intervention with paclitaxel-eluting stenting.
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DOI：
10.1007/s11606-009-1054-1
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发表时间：
2009-09
影响因子：
5.7
通讯作者：
van Domburg, Ron T.
中科院分区：
文献类型：
--
作者：
Pedersen, Susanne S.;Denollet, Johan;de Jonge, Peter;Simsek, Cihan;Serruys, Patrick W.;van Domburg, Ron T.
抑郁症与心脏病患者的不良预后相关，因此在临床实践中需要使用简单有效的工具来识别抑郁症患者。我们检查了两项患者健康问卷（PHQ-2）是否与经皮冠状动脉介入治疗（PCI）接受紫杉醇洗脱支架患者的不良事件相关（使用连续评分和各种截止值），总体和性别。前瞻性随访研究。在某大学医疗中心连续就诊的PCI患者（n = 796）。基线PHQ-2。研究终点为不良事件，定义为随访时死亡或非致死性心肌梗死（MI）的组合（平均1.4年）。在随访中，47名患者出现了不良事件。采用PHQ-2连续评分和推荐截止值≥3，抑郁症状与不良事件无相关性（ps > 0.05）。使用截断值≥2，抑郁症状与不良事件显著相关（风险比：1.89;95% CI: 1.06-3.35），并且在校正分析中仍然显著（风险比：1.90;95% CI: 1.05-3.44）。抑郁症状与男性不良事件风险增加相关（HR: 2.69; 95% CI: 1.36-5.32），但与女性无关（HR: 0.76; 95% CI: 0.24-2.43）；这些结果仍在调整后的分析中。采用两项量表进行抑郁筛查，截止评分≥2分与随访不良事件独立相关。PHQ-2是一种简单有效的测量方法，可以很容易地在PCI术后用于识别有不良健康结果风险的患者。
Depression is associated with adverse prognosis in cardiac patients, warranting the availability of brief and valid instruments to identify depressed patients in clinical practice. We examined whether the two-item Patient Health Questionnaire (PHQ-2) was associated with adverse events in percutaneous coronary intervention (PCI) patients treated with paclitaxel-eluting stenting (using the continuous score and various cutoffs), overall and by gender. Prospective follow-up study. Consecutive PCI patients (n = 796) seen at a university medical centre. PHQ-2 at baseline. The study endpoint was an adverse event, defined as a combination of death or non-fatal myocardial infarction (MI) at follow-up (mean of 1.4 years). At follow-up, 47 patients had experienced an adverse event. Using the continuous score of the PHQ-2 and the recommended cutoff ≥3, depressive symptoms were not associated with adverse events (ps > 0.05). Using a cutoff ≥2, depressive symptoms were significantly associated with adverse events (HR: 1.89; 95% CI: 1.06–3.35) and remained significant in adjusted analysis (HR: 1.90; 95% CI: 1.05–3.44). Depressive symptoms were associated with an increased risk of adverse events in men (HR: 2.69; 95% CI: 1.36–5.32) but not in women (HR: 0.76; 95% CI: 0.24–2.43); these results remained in adjusted analysis. Depression screening with a two-item scale and a cutoff score of ≥2 was independently associated with adverse events at follow-up. The PHQ-2 is a brief and valid measure that can easily be used post PCI to identify patients at risk for adverse health outcomes.
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影响因子：
17.7
作者：
de Jonge, P;Ormel, J;Schene, AH
通讯作者：
Schene, AH
DOI：
10.1097/00008483-200605000-00007
发表时间：
2006-05-01
期刊：
Journal of cardiopulmonary rehabilitation
影响因子：
--
作者：
Dunn, Susan L;Corser, William;Holmes-Rovner, Margaret
通讯作者：
Holmes-Rovner, Margaret
影响因子：
--
作者：
Parashar, Susmita;Rumsfeld, John S.;Vaccarino, Viola
通讯作者：
Vaccarino, Viola
影响因子：
6
作者：
Mueller-Tasch, Thomas;Peters-Klimm, Frank;Herzog, Wolfgang
通讯作者：
Herzog, Wolfgang
影响因子：
3.3
作者：
Frasure-Smith, N;Lespérance, F;Bourassa, MG
通讯作者：
Bourassa, MG