Early left-hemispheric dysfunction of face processing in congenital prosopagnosia: an MEG study.
Early left-hemispheric dysfunction of face processing in congenital prosopagnosia: an MEG study.
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DOI：
10.1371/journal.pone.0002326
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发表时间：
2008-06-04
期刊：
影响因子：
3.7
通讯作者：
Junghöfer M
中科院分区：
文献类型：
--
作者：
Dobel C;Putsche C;Zwitserlood P;Junghöfer M
先天性面容失认症是一种严重的面孔感知障碍，它不是由大脑病变获得的，可能是从出生就存在的。它主要表现为无法识别熟悉的人。电生理学研究已经证明了在170 ms左右达到峰值的负偏转与面部处理的相关性，相应地在脑电图（EEG）中标记为N170，在脑磁图（MEG）中标记为M170。M170被证明是敏感的反转的脸和熟悉的两个因素，被认为是至关重要的先天性面容失认症。为了定位认知功能障碍及其神经相关因素，我们研究了响应这些操作的神经活动的时间过程。七名先天性面容失认症患者和七名匹配的对照组参与了实验。为了及时高精度地探索大脑活动，我们记录了诱发磁场（275通道全头部MEG），同时参与者正在观看熟悉度（著名与未知）和方向（直立与倒置）不同的面孔。潜在的神经源估计的最小二乘最小范数估计（L2-MNE）的方法。行为数据证实了早期的研究结果受损的大脑处理先天性面容失认症。对于M170，总体结果重复了早期的发现，枕颞脑对倒置面孔的反应比直立面孔大，右半球比左半球活动更多。与对照组相比，先天性面孔失认症的参与者显示出大脑活动的普遍减少，主要是在左枕颞区。这种衰减与熟悉度或方向没有相互作用。这项研究证实了左脑半球早期参与面孔失认症症状的发现。这可能与一种有效的和过度使用的特征加工策略有关，该策略可以作为受损的特征加工的补偿。
Congenital prosopagnosia is a severe face perception impairment which is not acquired by a brain lesion and is presumably present from birth. It manifests mostly by an inability to recognise familiar persons. Electrophysiological research has demonstrated the relevance to face processing of a negative deflection peaking around 170 ms, labelled accordingly as N170 in the electroencephalogram (EEG) and M170 in magnetoencephalography (MEG). The M170 was shown to be sensitive to the inversion of faces and to familiarity-two factors that are assumed to be crucial for congenital prosopagnosia. In order to locate the cognitive dysfunction and its neural correlates, we investigated the time course of neural activity in response to these manipulations. Seven individuals with congenital prosopagnosia and seven matched controls participated in the experiment. To explore brain activity with high accuracy in time, we recorded evoked magnetic fields (275 channel whole head MEG) while participants were looking at faces differing in familiarity (famous vs. unknown) and orientation (upright vs. inverted). The underlying neural sources were estimated by means of the least square minimum-norm-estimation (L2-MNE) approach. The behavioural data corroborate earlier findings on impaired configural processing in congenital prosopagnosia. For the M170, the overall results replicated earlier findings, with larger occipito-temporal brain responses to inverted than upright faces, and more right- than left-hemispheric activity. Compared to controls, participants with congenital prosopagnosia displayed a general decrease in brain activity, primarily over left occipitotemporal areas. This attenuation did not interact with familiarity or orientation. The study substantiates the finding of an early involvement of the left hemisphere in symptoms of prosopagnosia. This might be related to an efficient and overused featural processing strategy which serves as a compensation of impaired configural processing.
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