IDENTIFICATION AND CHARACTERIZATION OF A PROSTAGLANDIN TRANSPORTER
IDENTIFICATION AND CHARACTERIZATION OF A PROSTAGLANDIN TRANSPORTER
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DOI：
10.1126/science.7754369
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发表时间：
1995-05-12
期刊：
影响因子：
56.9
通讯作者：
SCHUSTER, VL
中科院分区：
文献类型：
--
作者：
KANAI, N;LU, R;SCHUSTER, VL
Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function encoded by the rat matrin F/G complementary DNA was predicted to be an organic anion transporter. Expression of the matrin F/G complementary DNA in HeLa cells or Xenopus oocytes conferred the property of specific transport of prostaglandins. The tissue distribution of matrin F/G messenger RNA and the sensitivity of matrin F/G-induced prostaglandin transport to inhibitors were similar to those of endogenous prostaglandin transport. The protein encoded by the matrin F/G complementary DNA is thus preferably called PGT because it is likely to function as a prostaglandin transporter.
